Comparison of the effect of continuous and interval exercise on respiratory and inflammatory indicators of patients with Interstitial lung disease (ILD) candidates for lung transplantation

Comparison of the effect of continuous and interval exercise on respiratory and inflammatory indicators of patients with Interstitial lung disease (ILD) candidates for lung transplantation

Clinical trial with a control group, with parallel groups, a blinded, randomized, phase 3 on 30 patients, random number table and individual randomization unit were used for randomization.

This study is a blind strain and only the researchers responsible for data collection and analysis are not aware of the allocation of groups. A total of 30 patients referred to Masih Deneshvari Hospital in Tehran, Iran will be evaluated. Control group patients do 30 minutes of continuous exercises (treadmill) with 60% of the maximum exercise capacity. In the intervention group, interval exercises include 2 minutes of activity with an intensity of 80% of the maximum exercise capacity, and 2 minutes of recovery with an intensity of 50% (by treadmill). The duration of the exercises will be 30 minutes and over a period of 10 days.

Inclusion criteria include age above 18, consent to participate in the study, BMI in the range of 19-25, muscle force of hip flexors and knee extensors at least 4 out of 5, and patients undergoing oxygen therapy. Exclusion criteria include having pulmonary hypertension, PAP above 40, musculoskeletal problems limiting exercise.

Patients in the control group perform 30 minutes of continuous exercises (treadmill) with 60% of the maximum exercise capacity. In the intervention group, interval exercises include 2 minutes of activity with an intensity of 80% of the maximum exercise capacity, and 2 minutes of recovery with an intensity of 50%. (by treadmill).

Maximum exercise capacity, quality of life, shortness of breath and fatigue, PIMAX and PEMAX, DLCO, FEV1, FVC, CRP, ESR

Randomization is done with a simple randomization method using a table of random numbers and an individual randomization unit. For randomization, we use a table consisting of random numbers 1 to 8. Each of the figures in this table is repeated the same on average. There is no discernible pattern of numerical values. In this method, each figure is assigned to a treatment group. We start from the first row of the table and move down row by row. For the two treatments that will be performed, we put numbers 1 to 4 for treatment A and numbers 5 to 8 for treatment B. We continue the above process until two groups are complete.

This study is a blind strain and in order to prevent any kind of possible complications, the specialist doctor and the clinical caregiver are fully aware of the specialty of the treatment groups. Patients participating in the study were not blinded to the type of treatment they received. Only the researchers responsible for data analysis are not aware of the allocation of different study groups. Patient information will be provided to the data analyst in coded form in separate files.