Preparation and evaluation of topical glycyrrhizin-menthol-aloe vera gel and assessment its effect on the prevention of laser-induced dermatitis: a randomized controlled clinical trial

Preparation and evaluation of glycyrrhizin-menthol-aloe vera topical gel and its effectiveness in preventing laser-induced dermatitis: a randomized controlled clinical trial

A randomized controlled clinical trial with double-blind parallel groups of phase 2 is on 90 patients, and the patients will be randomly divided into 3 groups of 30 people based on the RAND() function of Excel software.

This study is a randomized clinical trial that is conducted on 90 patients at Yazd Laser Therapy Center. Taking into account the criterion of entering the study, the clients will be randomly divided into 3 groups of 30 people, including those receiving glycyrrhizin-menthol-aloe vera gel, placebo (base gel) or control (without medicine). Neither the doctor nor the patient knows the contents of the medicine containers

Clients who have started using laser and have no history of allergies to plants such as licorice, aloe vera and mint and no skin diseases

The group receiving glycyrrhizin, aloe vera, and menthol gel, which was made in the laboratory of the Faculty of Pharmacy of Yazd University of Medical Sciences under the supervision of the professors of the faculty and during the Ph.D. thesis of a pharmacy student, received topically for 15 days from the start of the laser. The control group received base gel without medication for 15 days from the start of the laser

at times 1, 2, 4, 7, 10, 15, the state of the laser site in terms of the loss of the epidermis, intensity of redness, dryness, itching (based on the table below), burning and pain (based on the visual scale VAS) and the patient's satisfaction with the use of the drug and whether the skin in the laser area gets second degree burns or not and the need to use standard dermatitis treatment are evaluated.

This study is a randomized clinical trial that is conducted on 60 patients at Yazd Laser Therapy Center. Taking into account the inclusion criteria, the participants will be randomly placed in three groups of 20 people including glycyrrhizin gel recipient, gel base, and control (without receiving any medication), and will receive the drug related to that group, based on the RAND() function of Excel software. The medicine is placed in uniform containers, and neither the doctor nor the participant knows about the contents of the tubes.

In this study, clients who have undergone laser hair removal will be included in the study after obtaining written consent. Taking into account the inclusion criteria, the clients will be placed in 3 groups of 30 people including glycyrrhizin-menthol-aloe vera gel, placebo (base gel) or control (without medicine) based on the random numbers table. They will use the prescribed medicine twice a day under the supervision of a doctor. Neither the doctor nor the patient knows the contents of the medicine containers. After the start of the treatment at times 1, 2, 4, 7, 10, 15, the state of the laser site in terms of the loss of the epidermis, intensity of redness, dryness, itching (based on the table below), burning and pain (based on the visual scale VAS) and the patient's satisfaction with the use of the drug and whether the skin in the laser area gets second degree burns or not and the need to use standard dermatitis treatment are evaluated

Only a part of the data, such as the information related to the main outcome or the like, can be shared.

One year after the time of publication

The data will be available only to researchers working in academic and scientific institutions

The data will be available only to researchers working in academic and scientific institution

The data will only be available to researchers working in academic and scientific institutions through the following email address. neginaseri@yahoo.com

Only the data related to the main results of the study can be presented to the mentioned people after mentioning the valid reason.