Preparation and evaluation of oral Syrup containing aqueous extract of Rosa canina L fruit and oleoresin essential oil of Pistacia Atlantica in improving the cough due to acute bronchitis

Determining the effect of oral syrup containing Pistacia atlantica oleoresin in improving subacute and chronic cough symptoms

The study is conducted as a randomized clinical trial with a control group, with two parallel groups and in a three-way blind (patient, doctor, data analyst) and patients are randomly divided into groups. Twenty-four non-smoking outpatients with chronic cough (duration of cough between 8 and 100 months) of any origin referred to Shahid Rahimi Hospital clinic from the beginning of 2014 to 2014.

Permuted block randomization so that first all 4 blocks containing two codes A and B are prepared (6 blocks) then random blocks are selected by placement using a table of random numbers. These blocks form a sample-sized sequence of A and B codes, each of which is randomly assigned to one of the groups. The list of relevant codes will remain confidential until the end of the project. The place of study is the doctor's office in Khorramabad.

Entry criteria: subacute (3 to 8 weeks) and chronic (more than 8 weeks) cough, age over 18 years Exclusion criteria: use of other antitussive drugs, opioids, sedatives, antihistamines, antibiotics, bronchodilators, history of asthma, history of chronic bronchitis, pneumonia, lung abscess or pulmonary tuberculosis, smokers.

Groups receiving three doses of syrup containing Pistacia atlantica oleoresin

The number of cough attacks per day and the number of coughs per attack Checking the quality of cough. In each examination, the level of recovery is evaluated as complete recovery (complete cessation of cough), partial recovery (the patient expresses satisfaction with the reduction of cough or the duration of cough is halved), no recovery (the medicine does not cause any change in the severity of cough).

Random allocation of patients into four groups and also using stratified random allocation. In this way, classes are made based on age group (below 30 years and greater than or equal to 30 years), cough severity (chronic cough, sub acute), body mass index status (less than 25 and greater than or equal to 25) are constructed (12 classes in total).. Within each class, random permutation blocks are used to assign samples to the required groups. To create random sequences, letters A, B , C or D(corresponding to the experimental group) will be used as follows. ABCD: 0-3 ABDC: 4-7 ACBD: 8-11 ACDB:12-15 . . DABC DBAC DCAB DCBA: 92-95 Then a corner of the table of random numbers is selected and two-digit numbers are read from top to bottom, and finally, according to the read number, a random sequence of letters A to D is registered in the desired floor. Finally, a random sequence of letters A to D (corresponding to the 4 experimental groups) will be created in each class of all existing classes, and the samples will be assigned to 4 groups based on this random sequence.

This study will be triple blind, which means that the pain intensity assessor, the patient and the data analyst are not aware of the type of treatment assigned to the patient. In addition, the decipherer is not a member of the research team and the edible syrups in all groups are completely identical in appearance. Data registration in the statistical software and data analysis is done by the statistical consultant without mentioning the names of the groups.

Only part of the data, such as information about the main consequence or similar, can be shared

Start the access period 18 months after printing the results.

Data will only be available to researchers working at academic and scientific institutions

The data will only be used to inform the results of the study

Lorestan University of Medical Sciences

Refer to Lorestan University of Medical Sciences, Vice Chancellor of Research and Technology, Research Projects Department, Management of Research Projects Department, 066333120175, Mrs. Sajedi , fax:066333120173 call mrs. zarei 0989167083314