Comparison of the therapeutic effect of verapamil and triamcinolone drugs and their simultaneous use with macroneedling in patients with Peyronie's plaque

Determining the therapeutic effect of verapamil and triamcinolone drugs and investigating their simultaneous use with macroneedling in patients with Peyronie's plaque.

The study is conducted as a clinical trial with a control group, with parallel groups, double-blind, randomized, on 60 patients. RNG plugin is used for randomization in excel software.

60 eligible patients who were selected from the patients referred to the Shahada Tajrish Hospital clinic in Tehran were randomly assigned to the intervention group or the control group. Standard medical treatment will be given to all patients, as well as the consent form will be explained to all patients about the process of intervention and the complications caused by it. Before the intervention and after the intervention, patients' information including the size of the plaque before and after the treatment, the amount of penile curvature before and after the treatment, the amount of erectile dysfunction before And after the treatment، (IIEF-5), the amount of pain during erection(VAS)is collected.

Entry requirements: Patients with Peyronie's plaque confirmed by ultrasound referring to Tajrish Martyrs Hospital Age 20-65 years Non-entry conditions: Having a history of trauma and fracture of the penis Having a history of previous surgery on the penis Having a history of pelvic radiotherapy

The intervention is performed by macroneedling and by a needle with a length of 8-10 mm The intervention process includes the injection of verapamil and triamcinolone drugs along with macroneedling technique 6 times a week at the site. In the control group, only verapamil and triamcinolone injections are performed

Erectile dysfunction; Pain; Curvature of the penis

First, by using the Random number generation plugin in Excel software, a table of random numbers from 1 to 60 is prepared in a non-sequential and scattered manner, and intervention and control are done by assigning numbers to two groups of 60 people. The randomization process is done by the study methodology consultant, and the clinical researchers do not know about the randomization process, and only randomized codes from 1 to 60 will be provided to them.

fter selecting the samples, none of the sampled people will know about randomization and the process of allocation to groups. Doctors are given a table of coded numbers in advance and patients are included in the study in the order of the numbers in the table. Therefore, the present study is double-blind. All patients receive routine medical treatment, but the macroneedling technique is performed for the case group, but this procedure is not performed for the control group.

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The access period starts immediately after the results are printed

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Hossein Rahnama via the email address below rahnama2010@gmail.com

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