Effect of probiotic prophylaxis on the prevention of ventilator-associated pneumonia (VAP) in patients admitted to the intensive care unit (ICU)

Effect of probiotic prophylaxis on the prevention of ventilator associated pneumonia ( VAP ) in ICU patients

A clinical trial with a control group with parallel and two-way blind groups, randomized by systematic random sampling method in such a way that an alphabetically sorted list of patients admitted to the intensive care unit . The determination of intervention and control groups will be based on the last digit of the patient's admission code ; Phase 3 on 134 patients .

Patients under mechanical ventilation and hospitalized in the General ICU of Masih Daneshvari Hospital. The examining doctor, the nurse prescribing medicine and placebo, the doctor recording vital signs do not know about the control and intervention groups.

Inclusion criteria include all patients over 18 years of age and intubated under mechanical ventilation in the intensive care unit. Exclusion criteria include the patient's diagnosis of VAP upon arrival; pregnancy ; prosthetic heart valve ; prosthetic vascular graft; immunosuppression ; history of rheumatic fever ; history of gastrointestinal damage in the current admission ; tracheostomy; unwillingness of the patient or his parents ; Intolerance of gavage .

The intervention group will be prescribed probiotic capsule by gavage and will also receive other standard treatments. The control group will receive standard treatments along with placebo capsules . Standard treatments to prevent VAP include position of the upper body at an angle of 30 degrees ; oral hygiene with chlorhexidine mouthwash ; interruption of sedation during daily periods and waking up the patient ; daily periods of spontaneous breathing .

Ventilator associated pneumonia; Length of stay in ICU; Length of antibiotic therapy.

The sampling method in this study will be systematic random sampling .For each patient in the first group, we will have one patient in the second group. The determination of the people of the first and second groups will be based on the last digit of the patient's admission code. In this way, the first patient whose last digit of their code is odd is placed in the intervention group, and vice versa, the first patient whose last digit of their code is even is placed in the control group.

The patient does not know which group is the study or the control group, the control group will receive standard treatments along with placebo capsules that look similar to the original capsules produced by Tekgen Biot. The number of drugs, the nurse who prescribes the drug, the examining doctor and the doctor who registers the vital signs do not know about the patient group.