Evaluating the effectiveness of taurine in reducing the incidence of ventilator-associated pneumonia inchildren undergoing mechanical ventilation in the pediatric intensive care unit of Shiraz Namazi Hospital arandomized, double-blind clinical trial

The effectiveness of taurine in reducing the incidence of ventilator-associated pneumonia in children under mechanical ventilation pediatric's intensive care unit of Namazi Hospital, Shiraz: a randomized, double-blind clinical trial.

A randomized clinical trial with the control group, with parallel groups, double-blind, phase 3 on 72 patients. A table of random numbers was used for randomization.

In this study, randomization is done using a table of random numbers. In a ratio of one to one, one group receives taurine 30 mg/kg in two divided doses and another group gets a placebo 30 mg/kg in two divided doses of carboxymethyl Cellulose is given. All patient information is recorded and analyzed after collection. This study will be conducted in Namazi Hospital affiliated with Shiraz University of Medical Sciences, Shiraz, Iran.

Inclusion criteria: all children from 3 months to 15 years who need mechanical ventilation for more than 48 hours and the completion of the ethical consent form by their parents, exclusion criteria before randomization: malignancy, AIDS, patients with heart failure, age Less than three months, Cystic fibrosis patients

Patients are randomly divided into two receiving groups: taurine or placebo (carboxymethyl cellulose) orally from the time of intubation until the patients are hospitalized in the PICU department.

The incidence rate of ventilator-associated pneumonia, The incidence of septic shock

All patients are randomly divided into two groups receiving taurine supplements or placebo by permutation blocking method. Quadruple permutation block randomization: All possible blocks are arranged as follows: Block 1: Block ABAB 2: Block AABB 3: Block ABBA 4: Block BBAA 5: Block BABA 6: BAAB We need 18 blocks to select 72 people. We choose these blocks randomly from numbers 1 to 6. For example, if number 6 is chosen as the first block and number 2 is chosen as the second block, the people entering the study will be given BAABAABB in that order. Finally, group A receives placebo and group B receives taurine.

In our study, the participants (patients) and the researcher do not know whether each patient received taurine or placebo. Taurine and placebo are both prepared in the form of 250 mg capsules with the same shape, color, and size and in the same packaging. Only one of the colleagues, who does not have a role in evaluating the results and analyzing the data, knows about the division of patients based on the table of random numbers.