Comparison effect of induced hypotension and normal blood pressure on Cognitive Function in patients candidate for rhinoplasty surgery

Determine the effect of induced blood pressure reduction on cognitive function in people candidate for rhinoplasty surgery in Rafsanjan

Clinical trial with a control group, parallel groups, double-blind, randomized, phase 2 on 50 patients.Random allocation software will be used for randomization.

Patients are randomly divided into two groups A and B. Induced hypotension will applied by Remifentanil, in group A but it is not applied in group B, and by tranxamic acid will be used to control bleeding. In this study, the researcher, person who responsible for following up the patients, the statistician were blind to the study.

Patients between the ages of 15 and 45, with the ability to read and write and "American society of anesthesiology" class,2, can enter this study. If the patients do not want to participate in the study, the history of blood coagulation disorder or the occurrence of anesthesia complication during surgery, such as airway spasm or desaturation, the subject will be excluded from the study.

In the intervention group (group A), remifentanil was used in order to reduce blood pressure, to control bleeding at the operation site, and the dose of remifentanil was adjusted so that the mean arterial pressure was decrease more than 30% of the bloop pressure before anesthesia induction or mean blood pressure decreases to 50 to 65. In the control group (group B), induced blood pressure is not given so that the patient's blood pressure is maintained above 50 to 65 mm Hg or lower than 30% of the initial blood pressure.

The individual's cognitive performance is compared by "minimum mental status test", Beck questionnaire and Paced Auditory Serial Addition Test (PASAT) after surgery in two groups.

Base on "Random allocation software" patients are randomly divided into groups A and B.

Based on the Random computer software, the patients are divided into groups, A and B. Induce hypo-tension is applied in group A. Participants, intervention outcome assessors, and researchers aware who is in group A or B, but none of them aware that whatever intervention group is group A or B. Finally, after interpretation of the results by the statistician, the observer reveals each name belonged to which group.

After making the participants unidentifiable, demographic information and the main outcome of the study, include the cognitive function of patients before and after rhinoplasty surgery, will be published.

The access period starts 18 months after the results are published

The findings and documentation of the article will be available to health researchers and the general public.

Any analysis on the released data is permitted

The e-mail address and postal address of the corresponding author of the article will be announced, and the data and documentation will be provided to the requester by the corresponding author.

After the email request for data and documents, they will be delivered maximum within six months