Comparison of the therapeutic effect of injectable pantoprazole and famotidine in patients with epigastric pain

Investigation and comparison of the therapeutic effect of pantoprazole and injectable famotidine in patients with epigastric pain referred to the emergency department of Khatam al-Anbia (pbuh) Zahedan in 1401

A three-blind clinical trial with a parallel, randomized group, data analysis and analysis with spss22.0 software

After the doctor confirms it as epigastric pain, the triage nurse gives a code to the patients according to the random table. And according to the previous announcement, the pharmacy colleague provides the medicine needed by the patient to his nurse based on the specific codes, and the nurses, without knowing the medicine, give the desired medicine a dose of 40 mg of pantoprazole or a dose of 40 mg of injectable famotidine diluted in 100 ml. Normal saline solution is prescribed as a rapid infusion for 2 to 4 minutes. Both drugs are the same in terms of color and appearance. In addition, all patients will not know about the studied drugs. Then the intensity of the patient's pain at time 0, 30 and 60 is evaluated based on the pain assessment criteria based on what is visible on the patient's face (VAS) and recorded in the information checklist.

Patients with epigastric pain referred to the emergency department of Khatam Zahedan Hospital in 1401 Non-entry conditions: Pregnancy, patients with unstable vital signs, receiving antacids/H2 receptor blockers/PPI within two hours before ED visit, known allergy to study agents, epigastric pain suspected of MI, age over 60 and under 18, cholecystitis, Suspicion of dissection

Patients with epigastric pain referred to the emergency room of Khatam al-Anbia, Zahedan

Pain intensity after drug injection

To perform block randomization, in cases where the sample size is small and the tendency is that in each stage of the study, the number of samples in both arms of the study is almost equal, from blocks of four (equal number of each group in each Block = we use two samples from group A and two samples from group B in each block of four. Here, we have six different modes for how the samples are distributed within each block: . AABB 2. ABAB 3. ABBA 4. BBAA 5. BABA 6. BAAB Assuming that the sample size is 100, we need 25 blocks. Using the software, we do 25 times random sampling from 1 to 6 (number of different blocks) with placement. The above table is a random sample of 25 times of sampling from six blocks (with placement). way to do: The first block is block number 4 (BBAA), which means that the first and second patients receive drug B, and the third and fourth patients receive drug A. The next block is block 2 (ABAB) and as a result, the fifth person is drug A, the sixth person is drug B, the seventh person is drug A, and the eighth person is drug B, and so on.

This study is a three-way blind study, so that the patient, doctor, and nurse do not know about the injectable drug, and only the pharmacist knows about the type of injectable drug, and the burial method is such that a code is given to each patient according to a random table, and the colleague According to the previous announcement, according to the code, the pharmacy provides the relevant medicine to the nurse The injection method of both drugs as well as the color and shape of both drugs are the same

All data can be shared after de-identifying individuals

The access period starts one month after the results are published

All researchers working in academic and hospital institutions and pharmaceutical companies

It is allowed to be used in research and treatment works by mentioning the source

mahjoubehkeykha@zaums.ac.ir Saharyoosefi96@gmail.com

After sending an e-mail and a sufficient explanation about your desired research and the reason for using data information, the necessary checks will be done as soon as possible and then you will be allowed access.