The effect of probiotic yogurt and exercise on the muscle mass, muscle strength, anthropometry and biochemical parameters and GI quality of life in post-bariatric surgery patients

Determining the effect of yogurt containing probiotics and exercise on muscle mass, muscle strength, anthropometric and biochemical indices and gastrointestinal quality of life in patients after bariatric surgery.

This study is a randomized, double-blinded, controlled clinical trial with four parallel groups (3 intervention and one control groups). 52 individuals (13 in each group) were randomized into groups with balanced-blocked randomization.

52 eligible individuals referred to Hafez and Ghadir hospital,Shiraz, after becoming informed and obtaining informed consent, will be randomly assigned into 4 study groups.They receive yogurt and exercise program according to their group.The yogurt bottles named the same as the groups with the letters A, B to blind the participant and the researcher and they take it daily for 8 weeks. Body composition, muscle strenght, anthropometric and biochemichal indices and gastrointestinal quality of life score will be assessed before and after the study

Inclusion: Age over 18 years and being candidate for bariatric surgery, absence of disease or special sensitivity Exclusion: unwillingness to continue cooperation for any reason or any complications after the operation, not following interventions and suffering from disease or infection

1. Receiving 120 cc of low-fat yogurt containing Bacillus coagulans + Lactobacillus plantarum probiotics in the amount of 1010 bacteria per day for 8 weeks along with resistance training program 2. Receiving 120 cc of yogurt containing the desired probiotics for a period of 8 weeks 3. Receive 120 cc of plain low-fat yogurt for 8 weeks along with resistance training program 4. Receiving 120 cc of plain low-fat yogurt for 8 weeks as a control group

muscle mass , muscle strength

Randomization will perform using the random block method (1: 1: 1:1 ratio) for four groups (one control and three intervention groups). In this method, blocks of four with rotation will be created by an out-of-study person. Then, a block will be randomly selected to determine the groups assigned to the first four participants. The random-blocks selection process will be repeated to determine the random allocation for the entire sample size. For allocation concealment, after determining the random sequence, these sequences will be placed in numbered sealed opaqued envelopes for each participant. An out-of-study person familiar with randomization will perform this process. During the study, by entering any participant in the study, based on the sequence, an envelope will be opened and the allocated group will be revealed

In this study, for blinding the interventions, enriched yogurts and placebo are the same in terms of color, odor, and taste and will be named A and B. The process of filling yogurt containers and naming them will be done by an out-of-study person. Therefore, in this study, the research team and the participants of different groups will be blinded to the type of the interventions or placebo consumed by each participant in order to observe the principles of blinding. For the exercise intervention group, the program is designed individually and home-based and the participants are not aware about each other's intervention.