Comparison of the healing effect of dressing 2nd and 3rd degree burns with silver sulfadiazine cream compared to povidone iodine in patients with 30% to 50% burns: a clinical trial

Comparison of healing of 2nd and 3rd degree burns in dressing with silver sulfadiazine ointment compared to povidone iodine in 30% to 50% burns in a year in Taleghani Hospital, Ahvaz

It is a double-blind study, a phase 3 clinical trial with a parallel group design of 82 patients. A randomized chain was used to enter the study using the Sealed Envelope online software.

Patients are selected based on admission criteria in Taleghani Hospital, Ahvaz, and randomly divided, and then each patient is treated with only one treatment, i.e. silver sulfadiazine dressing until the end of treatment, the second group is treated with povidone iodine impregnated gauze dressing until the end of the course, and then Each of them is compared in terms of the rate and speed of recovery, the patient's tolerance and cooperation during the period, the number of times of wound excision and going to the operating room, and the cost of treatment.

Inclusion criteria: The percentage of 2nd and 3rd-degree burns is between 30% and 50%. Patients aged between 20 and 65 years Not having underlying diseases that interfere with wound healing (diabetes, neurovascular, chronic kidney disease) Not having any underlying skin diseases (ehlersdanlers, pemphigus). Exclusion criteria: Having underlying anemia pregnant women

Patients with 2nd and 3rd degree burns and with an area of 30% to 50% of the body surface and based on the inclusion criteria are included in the study.

Wound healing speed, pain level, inflammation level, side effects

• Randomization method and description of each method: block 4 • Randomization unit: individual • Randomization tool: online randomization (https://www.sealedenvelope.com/), sealed envelope • How to make a random sequence: create It will be done randomly. On the web (https://www.sealedenvelope.com). After selecting Create list, it specifies the number of groups (two groups), the block size (block of 4) and the length of the list (80) and based on that, it provides the randomization list. • Explanation of allocation concealment: sealed envelopes that are assigned to each participant upon arrival and are placed in one of two groups based on that.

It is a double-blind study, so that only the attending physician knows about the dressing method and the second surgeon supervises the wound healing, and the patient and staff are not informed. After the participants were evaluated in terms of the criteria for inclusion and exclusion the study, a random chain of the sample size is created using the Silden Volup online software, and the people are added to this chain in the order of their entry into the study. The one that was made is imported.

The only results related to the consequences and outcomes of the intervention are publishable. They are made available to researchers for further investigation.

The data become available after the paper is printed and published.

Researchers employed in academic and scientific institutions

In meta-analysis studies and conducting similar studies.

Please refer to the Deputy of Research and Technology at Jundishapur University of Medical Sciences. Within submitting a proposal and obtaining an ethics code from the ethics committee of this university, access to data should be provided for researchers.

Researchers can access the data through correspondence with the Deputy Office of Research and Technology at the university and since obtaining the ethics code from the Ethics Committee in Ahvaz University of Medical Sciences.