It is clear that random block permutations of four can be generated in the following ways:
(0, 0, 1., 1). (0, 1, 0., 1). (0., 1., 1., 0). (1., 1., 0., 0). (1, 0., 1., 0). (1, 0., 0., 1)
In order to obtain a random permutation in each block, two numbers were selected by a simple random method from the numbers one to four by the software and were considered as group Zero and two unselected numbers were considered as group One. In this way, the allocation status of the participants to the intervention and control groups was determined in the order of entry into the study. Another 15 blocks of size 4 were produced in the same way. Selected codes were numbered from 1 to 60. Using a random number table for each row, a three-digit number was assigned as a drug code. Finally, the generated list was provided to the pharmacist so that the drugs and placebos could be coded accordingly. To blind the third phase, assigning code 1 to the drug or placebos was left to the pharmacist, to be decoded after data analysis is completed.
Double Blind. In this study, the vaginal product containing Cucurbita pepo L. subsp. pepo fruit is prepared in the form of cream and is packed in a tube and coded after putting a label. Vagisoft cream is also prepared with the same color and in the same packaging and coded. Therefore, until the encoding, it is not possible for the participants, principle investigator, healthcare providers, data collectors, outcome assessors, manuscript writers to distinguish the medication of the intervention group from the control group.