Investigating the effect of ferrous sulfate on thyroid function in pregnant women with acquired hypothyroidism in the second trimester of pregnancy

Determining whether correcting iron deficiency in pregnancy helps to improve thyroid function

Clinical trial with control group, with parallel groups, single blind, randomized, phase 3 on 48 patients, all information will be done using spss version 21.

This study will be conducted as a randomized clinical trial study on pregnant women with acquired hypothyroidism referred in the second trimester of pregnancy. This study is a blind strain and the participants are blind and uninformed.

Inclusion criteria: pregnant mothers with a positive pregnancy test result, age 20 to 35 years, and the pregnancy time is the second trimester of pregnancy, and informed consent will be obtained from all patients. Exclusion criteria were: suffering from chronic diseases (such as diabetes). Gastrointestinal intolerance of iron pills, all cancers and neoplasms, especially thyroid cancer.

.The study will be one-way blind in two groups, group A is the control group and group B is the intervention group. At the beginning of the study, 5 cc of blood will be taken from each patient, then for the intervention group, ferrous sulfate tablets, each tablet containing 50 mg of elemental iron, will be given two tablets equivalent to 100 mg of elemental iron daily, and for the control group, placebo tablets will be given daily. Two numbers will be given. After three months, 5 cc of blood will be collected from each group and the tests will be repeated in the same laboratory with the same kits.

Ferritin - TSH _hemoglobin _T3_T4 _ TIBC

For randomization, we use a table of random numbers. Suppose we are conducting a study in which there are two groups A and B. We assign each odd number to group A and each even number to group B. We close our eyes and Place your finger in the table of random numbers and write down the number of its column and row and specify the direction of your movement in this table. Suppose our starting point is the number 5 at the intersection of column 07 and row 07 and the direction of our movement is horizontal. to the right, so the first patient with the number 5 receives treatment A and we continue in the same way until the end. The allocation of the next patient is not predictable and this allocation is not one in between.

One way of blinding is the use of a placebo, that is, an inert substance that has the same taste and smell as Taher, although the use of a placebo in itself does not guarantee that the patients were blinded.

In this study, only a part of the data, such as the information related to the main outcome or the like, can be shared after making people unidentifiable.

The access period starts 3 months after the thesis defense

The data of this study will be available only to researchers working in medical and scientific academic institutions

Ethical considerations should be observed in all relevant aspects and analyses

Send a message to email poormobinaa97@gmail

Examining the person requesting information and the reason for his request for information, observing ethical considerations and checking in the university council, and sending the information if necessary.