Investigating the effect of curcumin supplementation on the dominant intestinal microbiome and butyrogenic bacteria in obese people under a weight loss diet

Determining and comparing the effect of curcumin supplementation on the dominant intestinal bacterial microbiome and butyrogenic bacteria in obese people under a weight loss diet compared with placebo

Clinical trial with the intervention and control groups, parallel, double blinded, randomized, phase III will perform on 80 participants with overweight and obesity. At the first,participants will randomize based on codes to A and B by the code-holder. codes will decoded after statistical analysis.

Obese and overweight people refer to Shafiyeh Zanjan clinic to lose weight

inclusion: Adults aged 18-50 years old, with body mass index equal-higher than 27.5 kg/m2 who refer to the specialized clinic to lose weight, will be selected. un-included: pregnancy or breastfeeding, lack of informed consent to participate in the study, presence of malignancies, chronic liver disease (fatty liver confirmed by ultrasound), renal failure (serum creatinine ≥ 2.0 mg/dl), dialysis), inflammatory diseases. Chronic conditions such as rheumatoid arthritis and acute infections, thyroid disorders (such as hypothyroidism or hyperthyroidism), blood sugar disorders including fasting or two-hour diabetes or other types of diabetes, receiving hormones or other herbal treatments, and allergies to turmeric or any spice, people on a special diet, intake of pro kinetic and anti acid drugs, gastrointestinal disorders. Exclusion: unwillingness to pursue the study. intake of antibiotic in any step of study

The first group will intake curcumin supplement with the dose of 500 mg and the second group will intake placebo containing 500 mg starch, two times per day, one drug in each time, with the lunch and dinner meals.

population of the dominant gut phyla and some butyrogenic bacteria

Blocked randomization will be used as two groups with 8-number blocks including 5 participants in each group. Randomization unit is person and we will use random allocation software for this purpose. random coded boxes will be used for concealment.at this method, cans with similar weight, shape and color which are numbered according to the random sequence will be used.

The drug and placebo are similar in appearance, color, smell, shape and packaging, and they will receive codes A and B. Participants will also be assigned to the code A, B. The main researcher and the participant are not aware of the arrangment in the groups and will only participate in the study with the assigned codes. Statistical analyzes will also be based on the codes. After ending the study, the codes will be decoded and the results will be reported.

It will be made available to the research and technology vice-chancellor of Islamic Azad University, Zanjan Branch

after paper publication

researchers based on the request to the corresponding author of the paper

for future studies or metaanalysis

Islamic Azad University, Zanjan Branch, Arazi Paeen Kooh, Daneshjoo Blv, Zanjan Tel: 024-33469500, postal cod: 45156-58145

request by the electronic e-mail to Mrs. Roqaye Mansouri under the e-mail address mansouri8801@gmail.com