A comparative study of the effect of intravenous administration of ketorolac and acetaminophen on pain relief after Uvulopalatopharyngoplasty surgery

Comparison of effect of intravenous administration of ketorolac and acetaminophen (Apotel) on pain relief after uvulopalatopharyngoplasty(UPPP) surgery

Referees for Uvulopalatopharyngoplasty surgery were divided into two groups based on the random numbers table. To the first group, Ketorolac 0.5 milligram/kilogram (maximum dose 30 milligram) was given intravenously half an hour before the end of surgery and then every 8 hours to 24 hours, and in the second group, acetaminophen (Apotel) 15 milligram/kilogram (maximum dose 1 gram) half an hour. Before the end of surgery and then 1 gram was prescribed every six hours for 24 hours. Then the pain level was evaluated based on Visual Analogue Scale (VAS) at half, 6, 12, 24 and 48 hours after surgery. The time to start swallowing liquids and solids was compared between the two groups.

patients aged 18-55 who had referred to ShahidSadoughi Hospital for the treatment of obstructive sleep apnea by UPPP

Inclusion criteria included patients with ASA 1 and 2, body mass index˂35. Exclusion criteria were any heart disease, uncontrolled blood pressure, uncontrolled diabetes, gastrointestinal problems, including (GERD), patient non-cooperation, use of anticoagulant drugs, drug abuse, use of corticosteroids, kidney disease, and surgery length of more than 2 hours.

To the first group, 0.5 milligram/kilogram (maximum dose 30 mg) of intravenous ketorolac half an hour before the end of surgery and then every 8 hours to 24 hours after surgery, and to the second group, acetaminophen (Apotel) 15 milligram/kilogram (maximum dose 1 gram) ) was administered half an hour before the end of surgery and then 1 gram every six hours until 24 hours.

intensity of pain need for drugs Time to start swallowing liquids Time to start swallowing solids

Among the 60 patients who come for this surgery during this period, we want to select two groups of 30 people for interventions. First, we consider the numbers 1 to 60. In the table of random numbers, the two digits on the left side of each number are used as the decision criterion, and after selecting the numbers randomly from the table, according to the contract, even numbers will be placed in the ketorolac intervention group and odd numbers will be placed in the acetaminophen intervention group. ,

The participants are unaware of the type of drug received. The drugs of both groups are prepared by the resident and will be available to the anesthetist in the operating room and the nurses in the ENT department. The follow-up person in the operating room and ENT department is unaware of which group each person is in. The data will be coded based on the number and the person analyzing will not know about the groupings.

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