The effect of eight weeks of high intensity interval training combined with thyme extract on serum levels of omentin, FGF-21, irisin, adropin and nesfatin-1 in sedentary young girls

The purpose of this research is to investigate the effect of eight weeks of HIIT training along with thyme consumption on the serum levels of omentin, FGF-21, irisin, adropin and nesfatin-1.

The clinical trial has a control group, with parallel groups, double-blind, randomized, with supplements and placebo on 48 patients. The rand function of Excel software was used for randomization.

Intervention - The city of Golpayegan is the location of Golpayegan University of Technical and Engineering research, for which the necessary arrangements have already been made. The present research method was field based. After calling and selecting the qualified people, the consent form for participating in the research was completed by the subjects and then the people were randomly placed in the periodic training, thyme, periodic training + thyme and control groups. The interval training group did intense interval training for 8 weeks. The thyme group received thyme supplement capsules (a product of Barij Essence Company) three times a day for 8 weeks. The intermittent exercise + thyme group underwent both exercise and thyme consumption. In the control group, the girls continued their normal life with placebo. In this research, the researcher and the participants were blinded.

Entry criteria include being in the desired age range, not having nutritional sensitivities, not having movement problems, and not having a regular sports history for at least the last 6 months. And the non-entry criteria include underlying diseases, skeletal complications, smoking, and nutritional sensitivities.

Interval training group, Thyme group, Interval training + thyme group, Control group

Omentin, FGF-21, Irisin, Adropin, Nesfatin-1

In this research, after selecting the eligible subjects, the subjects were selected by simple random method with the rule of random allocation. To place each subject in one of the four groups, a lottery was done in Excel; In this way, the list of participants was entered in one column in Excel. Then the RAND function was used to assign a random number to each cell (1 to 48). After that, names were extracted from the original list returned by RANDBETWEEN using the Index Rank function randomly and based on the row number. Finally, using Index Rank, four groups were selected, each containing 12 participants.

This study is a double-blind study. Due to the fact that the researcher and the subjects are not aware of the group and supplement consumed, a third person who is not aware of the objectives of the study will perform the supplement and groupings. Also, the third person codes them randomly and will be presented to the researcher with the code. It should be noted that all subjects will be informed about the research and objectives, but they will not be given information about which group they are in. Data analysis will also be done by a biostatistician outside the group who has no knowledge about the subjects.