Investigating the healing effects of topical spray containing effective herbal ingredients on burn wounds of patients with grade 1 and 2 burn wound

Investigating the restorative effects of the local spray of effective plant substances on burn wounds of patients with 1st and 2nd-degree burns.

This study is a 3-blind randomized clinical trial and is conducted on 40 patients who are selected by the available sampling method and based on the inclusion criteria and randomly divided into 4 groups of ten.

The research starts from the first appearance of first-degree burn symptoms in the hospital. During the study period, the surface area of the burn wound is measured every 24 hours until the burn wound is completely healed. The examining doctor and nurse, the patient and the statistical analyst are blinded in this study.

Inclusion criteria: - Age group from 10 to 70 years - Having first and second-degree burns, at least one square centimeter of the skin surface - Full alertness and being able to understand instructions and self-care (including not rubbing, touching and scratching the burn site) Exit criteria: - History of allergy to herbal medicines - Use of anti-inflammatory drugs (glucocorticosteroids, NSAIDs) in the last three months - The presence of a skin lesion that prevents the examination of burns - Diabetic patients and diabetic ulcers

The first group received Silver Sulfadiazine SSD cream in the burned areas every morning and received herbal topical spray 12 hours later. The second group receives topical plant spray on the mentioned areas every day both in the morning and 12 hours later. The third group, the positive control group, received SSD every morning and twelve hours later. The fourth group, the placebo control group, received SSD every morning and twelve hours later placebo or Oserin.

The surface of the lesion; color of the lesion; the presence of pain; degree of dryness of the lesion; satisfaction level

To randomize the patients, the random block method with a block size of four is used. For this purpose, four sheets of paper are prepared. The letter T (test) is written on two sheets and the letter C (control) is written on the other two sheets. The sheets are mixed and placed in a box. With each eligible patient's visit, one of the sheets is randomly drawn and based on whether the drawn sheet is T or C, it is assigned to one of the two test or control groups. It should be noted that the drawn cards are not returned to the box until all four cards have been drawn. After randomly pulling out all four sheets, all the sheets are returned to the corresponding box and the above procedure is continued for the next four patients until the desired sample size is reached.

The bottles containing the solution of herbal active ingredients are marked as X and the bottles containing the placebo are marked as Y, and only the researcher is aware of the contents of the spray bottles; The examining doctor and nurse, the patient himself and the statistical analyst, none of them know about the content inside the labelled bottles.

Data related to the effectiveness (qualitative and quantitative) of the medicine used by each participant can be shared.

The data will be shared immediately after the results are published in reputable journals.

The data will be available to researchers and industry practitioners.

The data can be used provided that the source is cited and referenced to the original study conducted by the executive team of this research, and their material and intellectual rights are respected.

The person responsible for coordinating the receipt of data and information is as follows: Dr. Firouz Payrvand Novin Medical Radiation Institute fpayervand@yahoo.com 02188086783

After communicating with the mentioned responsible person, the required data will be provided with the mentioned conditions within 1 month.