This cross-over randomized clinical trial aims to determine the effect of moderately-restricted dietary carbohydrate and it's replacement with fats on serum levels of adipocytokines, inflammatory indices and biomarkers of endothelial function among 40 women with metabolic syndrome aged 20-65 y. Non-pregnant and non-lactating women with body mass index greater than 25 that have not affected by gastrointestinal, renal, liver and thyroid disorders, diabetes, rheumatoid arthritis, Lupus, sever infection, trauma, surgery and allergy and also have not used medications that would affect carbohydrate and fat metabolism, blood pressure and inflammations during 3 mo ago will be included in this study. This study would compare the effect of usual Iranian diet (60-65% of energy from carbohydrates, 20-25% from fats and 15-17% from proteins) with that of moderately-restricted carbohydrate diet (43-47% of energy from carbohydrates, 36-40% from fats and 15-17% from proteins) on serum adipocytokine levels in a cross-over design. In this study, participants would have a 2-week run-in period, followed by a 6-week intervention and then a 2-week washout period followed by the second phase of a 6-week intervention period. Anthropometric measures, body composition, blood pressure, biochemical measures including fasting plasma glucose, serum insulin, triglyceride, total-cholesterol, high density lipoprotein cholesterol (HDL-c)-, and low density lipoprotein cholesterol (LDL-c), blood urea nitrogen (BUN), creatinin, E-selectin, high sensitivity C-reactive protein (hs CRP), high sensitive interleukin 6 (hs IL-6), high sensitive tumor necrosis factor-alpha (hs TNF-α), serum amyloid A (SAA), serum inter-cellular adhesion molecule (sICAM-1), serum vascular cell adhesion molecule (sVCAM-1), leptin and adiponectin levels would be measured at the beginning and end of phase I and II. To assess the compliance of the participants, we will assess dietary intakes of subjects by the use of dietary records once in every two weeks. Physical activity levels will also be assessed by a physical activity record once in every two weeks. Appropriate statistical methods will be applied for data analyses.