Metabolic Impact of Exercise Modalities in Inactive Overweight and Obese Adults: A Randomized Controlled Trial

the objective of this study was to assess and compare the efficacy of various exercise modes (aerobic, resistance training, and combined exercise) and changes over time in enhancing lipid profile changes and glucose tolerance among adults who are obese.

Randomized, three arm parallel group trial with blinded outcome assessment. Participants were randomly assigned to groups using a computerized system that generated a sequence of random numbers at an external site.

Our study recruited physically inactive volunteers (45-60 years, BMI > 30 kg/m2) from Debre Markos, Ethiopia (radio & notice boards). To minimize bias, data collectors were blinded to participant group assignments (single-blind design).

Eligible participants were those aged 45-60 with a BMI above 24.9, physically inactive, willing, and able to exercise. Exclusions included significant health conditions like cardiovascular, respiratory, or musculoskeletal disorders, uncontrolled diabetes, hypertension, infections, or recent severe medical events.

Intervention group 1 (The resistance training group): performed standing plantar flexion, squatting, machine leg press, neutral rowing, bicep curl, triceps pulley, dumbbell curl, and vertical bench press. The exercise routine involved three sets per session, with 8 to 12 repetitions at an intensity of 50% to 75% of their one-repetition maximum (1RM). Intervention group 2 (Aerobic exercise training group): They involved using a treadmill at an intensity level ranging from 50% to 75% of HR max, for 25–40 minutes. The control group (CG) engaged in a training regimen that combined the total volume of the RT and the endurance group AT. In each session, participants performed AT exercises before moving on to RT.

Glucose tolerance; lipid profile

In our clinical trial, randomization was achieved through simple random sampling, with individuals as the unit of randomization. A computerized random number generator created a sequence to allocate participants to their respective groups, ensuring each had an equal chance of assignment. Allocation concealment was implemented using sealed opaque envelopes, which were opened only after baseline assessments, to prevent selection bias and uphold the study’s integrity.

The outcome assessors and data analysts were masked to the group assignments of participants. This was achieved by assigning codes to participant groups that were only known to researchers. The assessors and analysts worked with these codes, devoid of any knowledge regarding which group each code represented. This method effectively prevented potential bias in the assessment of outcomes and the analysis of data, thereby upholding the integrity of the research findings.

The datasets generated and/or analyzed during the current study are not publicly available due to data security before publication but are available from the corresponding author on reasonable request.

Anonymized participant data and statistical code will be made available upon reasonable request to researchers for purposes of replicating procedures and results.

the data will be available after publication for 3 years

for the corresponding author on reasonable request.(firewa6070@gmail.com)

The data should be used solely for scientific research and educational purposes..

direct contact with corresponding author (firewa6070@gmail.com)

The entire process can take several weeks to a few months, depending on the complexity of the request, the volume of data, and the responsiveness of the applicant to any follow-up queries or requirements. Applicants are encouraged to plan accordingly and allow sufficient time for each step of the process.