Effect of one session of aerobic exercise with transcranial direct or pulsed current stimulation on food craving, food preference, and some psycho-cognitive factors related to appetite control in overweight and obese women

The effect of direct current and transcranial pulse stimulation and exercise training on food cravings, impulsivity, risk-taking decision making, food preference, appetite, and cognitive flexibility in obese and overweight women

A controlled, parallel-group, double-blind clinical trial on 15 patients. The website randomization.com will be used for randomization.

This study will be conducted at Razi University, each subject will be exposed to 3 different conditions of electrical stimulation of the brain in a random order and then, will perform a 30-minute endurance activity.

Criteria for entering the research: Age range from 18 to 50 years A resident of Kermanshah Body mass index (BMI) between 25 and 39.9 kg/m2 Being right-handed Having food cravings Obtaining a certificate of non-prohibition of participation in sports training program from the doctor Criteria for not entering the research: History of seizures, epilepsy or other types of neurological diseases The presence of implantable devices or pacemakers in the body Smoking, alcohol and drugs Abnormalities or musculoskeletal disorders Participation in weight loss programs in the past 6 months Participating in a regular exercise program in the past 6 months Menopause

This study is an intra-group and counterbalanced study in which the subjects are exposed to 3 different conditions of brain stimulation including: 1) direct current anodal stimulation, 2) pulsed current anodal stimulation, 3) sham stimulation (placebo effect) in the DLPFC region. will be placed. The duration of stimulation will be 20 minutes and its intensity will be 2 mA.

Changes in food craving, impulsivity, risk-taking decision-making, food preference, appetite, and cognitive flexibility

In this study, the order of subjects' exposure to 3 different conditions (3 different types of electrical stimulation of the brain) will be randomized by the Latin Squares method. To do so, first using the site www.random.org, a number between 1 and 15 will be randomly allocated to each subject as an identification code. Then, the English letters A, B, and C will be assigned to the three intervention conditions and a Latin Square will be created. In this case, a Latin square with three rows and three columns is created. Finally, participants 1 to 5 will be placed in the sequence of the first row, participants 6 to 10 will be placed in the sequence of the second row, and participants 11 to 15 will be placed in the sequence of the third row.

In this double-blind study, the researcher and participants will be blinded to the type of transcranial electrical stimulation used and the location of stimulation in each session. In this study, the Neurostim stimulation device will be used to induce direct current electrical stimulation in three separate sessions and three different modes including: 1) direct current anodal stimulation, 2) pulsed current anodal stimulation, 3) sham stimulation (placebo effect) became. For this purpose, a person outside the research team will be responsible for applying electrical stimulation in three test sessions. In order to blind the participants, after they sit on a special chair, the stimulating device is hidden from their view and is completely covered by a cover, and the electrodes are placed on the desired areas by the examiner. In order to blind the researcher, before the intervention, the researcher leaves the laboratory and returns to the test site after the stimulation period has passed and the electrodes are removed and the stimulation device is turned off. Also, in sham stimulation mode, according to standard protocols, active current is induced on the head for 30 seconds in order to induce the same sensation as in active stimulation mode, and then the current is cut off and the stimulation is deactivated.

All data can be shared after de-identifying the subjects.

6-9 months after printing the results

The head of the research team and executive researcher

Meta-analysis

If you need to receive documents, send an email to Ehsan Amiri, a member of the scientific faculty of Razi University, with the email address: e.amiri@razi.ac.ir.

In case of an official request, stating the relevant reasons and mentioning the complete details, the data will be sent via email after 72 hours.