Investigating of the the effect of Rosmarinus officinalis L.on anxiety, depression, sexual dysfunction sleep disorder and cognitive disorders in patients undergoing maintenance treatment with methadone, double-blind, with placebo-controlled trial

Determining the effect of rosemary on anxiety, depression, sexual disorders, sleep and cognitive disorders in patients undergoing maintenance treatment with methadone

A clinical trial with 2 groups, with parallel groups (intervention group: recipient of rosemary capsules containing 500 mg of the active ingredient of rosemary, every 12 hours for 4 weeks, control group: recipient of a placebo with the same color, smell and appearance but the content of an ineffective substance like starch, but with a similar scent), double-blind, randomized, phase 2 on 52 patients. Randomization is done using a table of random numbers.

Place:addiction treatment clinic of Shahid Beheshti Hospital, Kerman, drugs are given to patients in similar capsules for 4 weeks. randomization and allocation remain hidden from the researchers and participants until the completion of the statistical analysis.

Age between 18 and 60 years Literacy for reading and writing Proficiency in Persian language Methadone maintenance treatment No history of heart disease No diabetes Absence of liver and kidney failure Absence of pregnancy Epilepsy and life-threatening diseases Lack of chronic treatment with antidepressants Not receiving antidepressants, benzodiazepines, melatonin and other sleep medications during the past month Not having moderate to severe mental disability No history of allergic reaction to rosemary and similar products

Intervention group: receiving rosemary capsules containing 500 mg of the effective ingredient of rosemary, every 12 hours for 4 weeks. Control group: receiving a placebo with a similar color, smell and appearance, but containing an ineffective substance such as starch, but with a similar scent.

Anxiety, sexual disorders, cognitive disorder, sleep disorder and depression disorder

The study samples will be blinded in a two-way and randomly using a table of random numbers in one of two groups of 26 people receiving medicine or placebo. For randomization, people will be divided into two groups based on the order of even and odd numbers. It is divided and the placebo is given to the executive by the project partner and it is recorded and specified for the project partner.

The placebo is given to the executive by the project partner and is recorded and specified for the project partner. In this study, randomization and allocation remain hidden from the researchers and participants until the completion of the statistical analysis, so the researchers and participants in this study are blinded.

At the end of the study, part of the information including the effect of dexmedetomidine drug infusion on hemodynamic changes and sedation after coronary artery bypass surgery in opium addicted patients, after de-identifying the individuals, was shared with those interested in health, treatment and research. will be

6 months after data analysis

Researchers in the field of health and treatment

Part of the information included at the end of the study,

Marzieh Heydarzadeh - Email

Purpose of data access - request to e-mail