A comparative study of vaginal probiotic administration on the consequences of embryo transfer, microbial culture of the uterine cavity and vagina in infertile women undergoing frozen embryo transfer at Shariati Hospital, Tehran University of Medical Sciences.

The effect of vaginal probiotic administration on the consequences of embryo transfer, microbial culture of the uterine cavity and vagina

A randomized controlled clinical trial with parallel, double-blind, randomized groups.

In this study, about 153 people are randomly placed into two groups of 77 and 76 people. Unlike the control group, the intervention group will be given Lactovagin capsules. After the preparation of the endometrium, the embryo transfer process is performed. It is done in Shariati Hospital.

Inclusion criteria: infertile women between the ages of 18 and 40, no underlying diseases, no uterine anomalies, and no history of any surgery on the uterus and cervix. Exclusion criteria: the presence of underlying disease, the presence of uterine anomalies, drug use, and male infertility, the use of broad-spectrum antibiotics, hormonal drugs, alcohol, anticoagulants, immunosuppressive drugs, and corticosteroids during the last month.

From the beginning of the embryo transfer cycle, Lactovage capsules are prescribed once vaginally for one month. Preparation of the endometrium with conjugated estrogen starts from the second day of menstruation, after the thickness of the endometrium reaches the appropriate level by performing serial transvaginal ultrasound; Patients receive rectal progesterone suppositories for 4 days. In the control group, preparation of the endometrium with conjugated estrogen started from the second day of menstruation after the thickness of the endometrium reached the appropriate level by performing serial transvaginal ultrasound; Patients receive rectal progesterone suppositories for 4 days

Diversity of microbial cultures of the uterine cavity and vagina

In this study, we use the block randomization method so that after selecting patients according to the inclusion and exclusion criteria by selecting numbers from the table of random numbers and adapting to the blocks, patients are divided into study groups. To randomize the two treatment methods, we create 4 blocks in six different states, then select a number using the table of numbers, and determine the study groups by matching the numbers with the blocks. For example, if the first digit of our number is 1 to 6, select a block and the division is done, but if, for example, our number is 94071, the digit 9 is not valid and we select the next digit. Here, based on the block, we divide 4 people into groups. 1. TTCC 2. TCTC 3. TCCT 4. CCTT 5. CTCT 6. CTTC

In this study, people who are responsible for patient care and analysis of statistical data do not know about the treatment process and study groups, and information is provided to them in groups A and B.

All data is potentially shareable after unidentified individuals

Starting 9 months after publication

Only available for people working in academic institutions

No other condition is considered

hoseinimosa@sina.tums.ac.ir

1 year