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Study aim
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Determining the consequences of administration of serum with lower amounts of potassium in Hospitalized children in Hazrat Masoumeh Hospital, Qom.
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Design
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Clinical trial with a control group with parallel groups of a blinded randomized phase 3 on 114 patients. Blocking was used for randomization.
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Settings and conduct
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Patients hospitalized in Hazrat Masoumeh Hospital, Qom, are included in the study and the exclusion criteria are applied.
Patients are divided into two groups based on random block method.
In the intervention group, dextrose serum 5%
half saline does not contain potassium. In the control group, 20 meq/lit of potassium are added to their serum according to Nelson's reference
A blood sample is sent to check VBG and the serum level of serum electrolytes and Bun, Cr, urine sample. Then, the potassium serum level will be checked every 12 hours to 48 hours. If it drops more than 0.5 milliequivalents compared to the initial potassium of the patient or is less than 3.5, it will be removed from the study and potassium will be added to the patient's serum.
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Participants/Inclusion and exclusion criteria
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Children 1-16 years admitted to the hospital, who need serum therapy, are included in the study.
Exit criteria:
Renal failure, metabolic diseases, gastroenteritis,
Patients with heart dis. immunodeficiency, potassium serum level less than 3.5, patients with food intolerance, underlying kidney disease, age under 1 year, polyuria or anuric, drop more than 0.5 potassium after 12 hours.
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Intervention groups
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For children aged 1-16 years who meet the inclusion criteria, potassium-free dextrose half-saline serum is prescribed and the potassium level is checked five times at 12-hour intervals.
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Main outcome variables
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Serum potassium level of the first, second, third, fourth and fifth tests
, Serum levels of BUN, Cr and VBG
, Urinary volume