Comparative Evaluation of the Impact of Routine Calcium intake versus Recommended Calcium Intake in Patients Undergoing Total Thyroidectomy

Comparative determination of the effect of routine calcium treatment regimen and the recommended calcium intake regimen in patients undergoing total thyroidectomy

it is a randomized clinical trial study with a control group in a single-blind manner on 40 patients in 2 groups.

In a period of 12 months, among the patients referred to Sina Hospital in Tehran, who are candidates for total thyroidectomy surgery in 1402-1404, are included in the study. The patients in this study were candidates for surgery and resection of both thyroid lobes due to multinodular goiter or thyroid cancer. After selecting the patients, the serum calcium level of each person will be measured before the operation. Calcium levels of patients will be checked 12 hours before surgery and every 8 hours after surgery, patients will be checked for signs and symptoms of hypocalcemia and serum calcium levels, and the presence and absence of symptoms will be collected in the checklist.

Patients over 18 years of age, potential early diagnosis of thyroid cancer. planned surgery: complete and bilateral thyroidectomy, with or without various lateral neck extensions, absence of preoperative hypercalcemia, or Any type of kidney disorder that causes calcium metabolism disorder, absence of abnormal preoperative parathyroid hormone level or concomitant parathyroid diseases, absence of history of any type of thyroid or neck surgery.

Patients were randomly divided into two groups of routine treatment diet (500 mg calcium every 8 hours and 1000 units of calcitriol daily) and high dose calcium treatment (500 mg calcium carbonate every 8 hours, 0.5 microgram calcitriol every 12 hours and 500 mg calcifort every 6 hours)

Serum calcium level before and after surgery, Symptoms of hypocalcemia

Patients are randomly assigned to one of 2 treatment groups by block randomization method. Block randomization with different block sizes is used for random allocation. Block sizes are multiples of 2. Initially, block sizes are randomly selected. Finally, one of the different permutations is determined for the equal group size. Random numbers are done using Excel. The study will be done blindly. In such a way that the patients do not know the type of supplement received and the drugs are given to the patients in the same packaging without specifying the specifications, and only the researcher knows the type of drug prescribed and the doctor and the person in charge of evaluating the patients who talk to the patient, They do not know the prescribed medicine.

With the help of getting random numbers using Excel for each patient. The study will be done blindly. In such a way that the patients do not know the type of supplement received and the drugs are given to the patients in the same packaging without any specifications, and only the researcher knows the type of drug prescribed and the doctor and the person in charge of evaluating the patients who talk to the patient about the type of drug Prescribed do not know.

The entire data will be shared after unidentifying people personal data

6 months after publishing the results

Researchers working in academic and scientific institutions

In order to perform further research with the request from the scientific institute

Dear applicants will be referred to Sina Hospital's scientific Center for access to Documents and Data or the applicant can email the project executor. the email address is available. (amiratashi@sina.tums.ac.ir)

After receiving the letter from the project executor, the applicant can refer to Sina Hospital Research Center and after the approval of the executor, the documents and data will be available to executor within a week or the applicant can email directly to project executor so the executor provide the information