Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) with and without Physical Activity on Depressive Symptoms, Brain Map , Physical Condition and Sleep Quality of Depressed Patients

Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) with and without Physical Activity on Depressive Symptoms, Brain Map, Physical Condition and Sleep Quality of Depressed Patients.

A controlled clinical trial with parallel groups, a blinded Single, phase 2-3 randomized, on 45 patients with depressive disorder. Random blocks were used for randomization.

This study is conducted in a private clinic of psychological services in Tehran, patients with depression disorder are included in the study. Due to the fact that the patients do not know about the group allocation, therefore, a blind strain study is performed. We will place the patients in three groups of 15 randomly. The first test group will be affected by repeated stimulation and the second test group will be affected by repeated transcranial magnetic stimulation along with physical activity. The third group of 15 people is the control group, which will not be affected by any experiment.

Inclusion criteria: obtaining a score above 20 in the Beck depression Inventory, No history of seizures and epilepsy, no drug addiction, no history of seizures and epilepsy, aged 18 to 65 years. Exclusion criteria: not completing the questionnaires and having intracranial implants and any other metal object near the head.

30 patients with depressive disorder received repetitive transcranial magnetic stimulation (rTMS) with and without physical activity in 25 sessions of 20 minutes with current in the left DLPFC area with a frequency of 10Hz.

Physical condition improvement questionnaire, brain map measurement scale, Beck depression inventory and Petersburg sleep quality questionnaire are compared in two intervention and control groups, before the intervention and after the 25th session.

Patients are randomly assigned to the intervention and control groups using the random block method. Then random replacement is done by lottery method (one number will be assigned to each of the sampled people). We write down the numbers on paper, then fold them and put them in a container. We mix and stir the papers completely. Then we take out the papers one by one and place one number in the first group and one number in the second group, respectively. Then random application will be done. In this way, one group is known as "control group" and the other group is known as "intervention group". In this way, to randomly determine the "control group" and the "intervention group", we put the set of each group in two separate envelopes and put them in a container. Then we randomly take one envelope out of the container and assign it to the "intervention group" and the other envelope to the "control group".

Due to the fact that the patients do not know about the group assignment, a blind study is performed.

All data can be shared after de-identification.

Data can be made available 6 months after results are published.

Researchers in scientific and academic centers can access the data.

The data can be used in meta-analyses if the names of the main researchers are mentioned.

If you need data, write to firoozefadaee1@gmail.com.

After receiving the request and its review by the main researcher, the data will be sent to the applicant along with a letter of commitment stating that the data will not be published without the name of the main researcher within one month.