Comparing the prophylactic effect of adding magnesium to Metoral in reducing atrial fibrillation after coronary artery bypass graft surgery

Determining the prophylactic effect of adding magnesium to Metoral in reducing atrial fibrillation after coronary artery bypass graft (AF post CABG) in patients who are candidates for coronary artery bypass graft (CABG).

This study is a randomized controlled clinical trial on 102 elective CABG patients. In this study, 102 patients will be divided into 2 groups (group 1 including magnesium + metoral, group 2 metoral alone).

Patients are admitted to Amirul Mominin Hospital from the day before the operation. Patients will be randomly assigned to 2 groups (magnesium + Metoral and Metoral only), also the drugs used will be prepared by the anesthesiologist (consultant professor) in syringes of equal volume with the same shape and appearance and then at the specialist's disposal. Anesthesia is responsible for injecting drugs.

Inclusion criteria -CABG candidate patients between 35-75 - are operated with that pump. -With informed consent -The average duration of surgery is 7 hours -There is no heart valve repair surgery along with CABG -ASAⅢ,Ⅳ patients -Not allergic to Metoral-Magnesium -have acid-base disorders resistant to treatment before surgery Exit criteria -suffer cardio-respiratory arrest during surgery. -do not agree to continue -need valve repair during surgery. -after the induction of anesthesia, the surgeon decides to perform surgery with the pump OFF. -have acid-base disorders resistant to treatment

The first group (Metoral + magnesium) (1-3 mg⁄kg/hour) put Metoral on the syringe pump, which is infused for 30 minutes, and at the same time, 2 grams of magnesium will be slowly injected for the patients. The second group (Metoral) 1-3 mg⁄kg per hour will be infused for 24 hours.

The occurrence of atrial fibrillation or other arrhythmias after surgery

In this study, CABG candidate patients referred to Amirulmomenin Hospital who meet the inclusion criteria and will be electively subjected to open heart surgery will be divided into two equal groups of magnesium + Metoral and Metoral. In this study, permutation random block method will be used for randomization. For this purpose, blocks of 6 will be used. In each block, the letter M (Metoral) is written on three cards and the letter S (Magnesium Sulfat) is written on three cards. Some of the selected random blocks of 6 are as follows: SMSMMS, SSMSMM, MSSMMS, SMSMSM, MSSMMS, MSMMSS, SMMMSS, MSSMMS, SMMSSM, SSMSMM. (For example, the method of random allocation in a block of 6 SMSMMS is as follows: the first patient to treatment S, the second patient to treatment M, the third patient to treatment S, the fourth patient to treatment M, the fifth patient to treatment M and the sixth patient to treatment S are allocated by accident.

The aforementioned study is a double-blind study in which CABG candidate patients who meet the inclusion criteria are included in the study after obtaining informed consent, but it does not matter which of the study groups (Metoral and Metoral + magnesium) they are in. They don't know. Also, the mentioned drugs in 2 groups will be prepared by the anesthesiologist (design consultant) in the same shape, size and volume, and labels 1 and 2 will be placed on them. Then the said syringes will be given to the anesthesiologist in charge of the plan, who does not know the type of groups, to be injected to the patients. Also, the intern in charge of the project, who is responsible for the questionnaires of the project, and the data analyst, do not know about the studied groups, so the study will be double-blind