Considering that this study is a randomized clinical trial with a 2*2 factorial design. According to the type of delivery (natural or caesarean section), all patients are assigned to 4 treatment groups and a total of 8 groups. In this way, you must first choose the type of delivery and choose the main and auxiliary drugs. receives. Randomization is done by block method (Permuted blocked randomization) with blocks of four (4 blocks in total). The method for easy work from Clin Trial Randomization software is group A, oxytocin and tranexamic acid, group B, oxytocin, group C, carbetocin and tranexamic acid, and group D, cartocin.
According to the table obtained from the randomization software, which of the above groups is prescribed to the patients in order. In all groups, there is a uterotonic drug that is necessary for the contraction of the uterine muscle after the baby is born.
In each group A, B, C, D, 2 syringes are ready for injection, one of them contains utrotonic and the other one contains tranexamic acid or empty normal saline as a placebo.
The homogenization of the drugs is that 30 units of oxytocin and 100 micrograms (1 ampoule) each are dissolved in 0.9% normal saline serum to a volume of 10 cc and drawn and homogenized in the same syringes. 500 mg of tranexamic acid is dissolved in 0.9% normal saline and reaches a volume of 10 cc, and is equalized against 10 cc of 0.9% normal saline serum drawn in the same syringes. Randomly, the sick midwife During a natural delivery and during a cesarean section, after the birth of the baby, the anesthesia technician injects two intravenous syringes from the drug group belonging to the patient who was separated according to the table.