Evaluating the effects of ethanolic extract of propolis mucoadhesives on palatal epithelial wound healing and post-operative complications after free gingival graft surgery

Evaluating the effect of ethanol extract of propolis mucoadhesive on palatal epithelial wound healing and complications after free gingival graft surgery.

Randomized clinical trial with a control group, with parallel groups, double-blind, randomized, phase 0 on 32 patients. For randomization, kitset.ir will be used.

This clinical trial was conducted in the periodontics department of Babol Dental School with 32 patients who were randomly divided into two groups and free gingival grafting surgery was done in the same way for both groups and 2 substances produced by the pharmacologist randomly are placed in the palate donor site in two groups, will be done. In this study, the patients, the researcher and the data analyst are not aware of the type of substance used between the groups.

Inclusion criteria: Patients over 18 years old Patients who need free gingival graft Sufficient dimensions of the free gingival graft donor site in the palate (length:10-15 mm, width: 5-8 mm, thickness:1-1.5 mm) Exclusion criteria: Systemic diseases and conditions affecting wound healing (such as uncontrolled diabetes, autoimmune diseases, history of alcoholism) Clinical attachment loss (greater than 3 mm) in the palatal site of premolars and maxillary first molars. Use of corticosteroids ، antibiotics in the last month Pregnancy or breastfeeding smoking Allergy to amoxicillin-ibuprofen-chlorhexidine mouthwash ,bee products Asthma

32 patients who referred to periodontics department of Babol Dental School are selected and divided into two groups of 16 member and the substances produced (A-B) will be randomly placed in the ulcerated palate donor site

The response to pain Response to thermal stimulus Epithelialization and degree of color adaptation, contour and distortion of the palate site

In this randomized clinical trial in order to randomize participants in different study groups, the kitset.ir will be used and the random number generation option will be done to determine case and control groups.

The studied groups are not informed in order to enter the case or control group in surgery. Patients do not know which type of mucoadhesive is placed in their palate wound area Researcher is not informed about the type of substance used between the case and control groups. The data analyst is not informed about the type of substance used between the case and control groups. The placebo in this study is the mucoadhesive group without propolis

The data will be identified and stored by assigning a code

The access period starts 12 months after the publication of the article

Researchers working in academic and scientific institutions

According to the acquisition of the code of ethics of the researchers by the Vice-Chancellor of Research and Technology of Babol University of Medical Sciences, the documents will be usable

Dr. Niloufar Jenabian - Babol University of Medical Sciences

Checking the eligibility of the applicant and having a code of ethics will be done by an academic center.