The effect of lidocaine infusion during laparotomy surgery on the reduction of postoperative pain and the amount of opioid consumption to control postoperative pain.

The effect of lidocaine infusion during laparotomy surgery on the reduction of postoperative pain and the amount of opioid consumption to control postoperative pain.

A controlled, parallel-group, phase 3, randomized, double-blind clinical trial on 60 patients. A table of random numbers was used for randomization.

The current study is a clinical trial on patients undergoing laparotomy surgery referred to the hospitals of Shahid Beheshti University of Medical Sciences. In the intervention group, 1% lidocaine was administered with a bolus dose of 1mg/kg as a slow intravenous injection, and then its infusion continued with a dose of 1mg/kg/h until the end of the operation. In the control group, normal saline infusion is used instead of lidocaine.

Inclusion criteria include no sensitivity to local anesthetics, no chronic use of narcotics and painkillers, no use of steroids, age between 18 and 85 years, no pregnancy, ASA Class one and two patients. Body mass index less than 40 kg/m2, heart rate more than 50 beats per minute, recovery time less than 45 minutes, interval between P wave and R wave in ECG not more than 0.2 seconds. Exclusion criteria include severe drop in blood pressure, severe bradycardia, moderate reduction in arterial pressure, arrhythmia or Urticaria, or patients whose surgery lasts more than 4 hours.

In the intervention group, after induction of anesthesia, administration of 1% lidocaine with a bolus dose of 1mg/kg as a slow intravenous injection It is done and then its infusion continues with a dose of 1mg/kg/h until the end of the operation. In the control group, normal saline infusion is used instead of lidocaine.

The intensity of the pain; the amount of systemic painkillers; Length of hospitalization

For randomization, a table of random numbers was used, in order to create a random sequence using a table of random numbers by a statistical consultant, the patients were randomly given one of the even and odd codes, the patients with even codes were placed in the first group and the odd codes were placed in the second group.

Medicines in envelopes that are similar in appearance are labeled as group A and B. The patient does not know about this labeling, nor does the drug distributor's colleague know about the labeling. In order to avoid any possible complications, the main researcher is aware of the allocation of groups.