Comparison of the effect of intravenous paracetamol (Apotel) and dexamethasone in the relief of acute migraine headaches referred to the emergency department

Comparison of the effect of intravenous paracetamol and intravenous dexamethasone in the relief of acute migraine headaches referred to the emergency department of Razi Hospital Birjand in 2024

Clinical clinical trial, one blind, randomized and on 80 patients in two groups.

Patients in the emergency room are randomly divided into 2 groups. One group receives 1 gram of intravenous paracetamol and the other group receives 8 mg of intravenous dexamethasone.

Patients aged between 18 and 60 years without a history of specific neurological disease who have experienced a migraine headache at least once. No history of continuous use of narcotics and long-term painkillers. Conditions for exclusion from the study: pregnancy, history of neurological disease, patients without personal consent, having a body temperature higher than 37.7 degrees Celsius, having a diastolic blood pressure higher than 105 mm Hg, patients being treated with systemic corticosteroids, allergy to dexamethasone, eggs Be careful, patients with a history of diabetes mellitus, active gastrointestinal ulcers, myocardial infarction in the previous week and hypokalemic familial paralysis (for dexamethasone). Continuous use of narcotics and long-term painkillers.

Intervention group A:receiving interavenous paracetmol with a dose 1 gram. Intervention group B:receiving interavenous dexametasone with dose 8 Mg.

Determining the amount of response to pain in two groups; determining and comparing the time after injection until relief; comparing the frequency of complications in the two groups; estimating the duration of hospitalization in the emergency room after injecting drugs; estimating the level of satisfaction with pain reduction

The classification of patients and the type of drug used for the people involved in the research were blinded, and the researcher evaluating the patients was not aware of the drug group prescribed for the patients during the study. For this purpose, all the syringes of both groups have the same appearance and volume with the frequency of use coordinated in both groups. Also, other common treatment measures are implemented for both groups. Therefore, the study will be conducted in a double-blind manner.