Comparing the effect of bromelain and placebo on primary dysmenorrhea pain on female students

Determining and comparing the average of primary dysmenorrhea pain intensity in women receiving bromelain and placebo, before and after the intervention.

A clinical trial with a control group, with parallel groups, triple-blind, randomized block

In this study, patients are randomly divided into two groups. The first group receives Anaheal GDU500 capsules (containing 200 mg bromelain GDU/g 2500), (GDU= Gelatin Digesting Unit) and the second group receives placebo. In order not to identify, both groups are prepared in uniform packaging and a unique code will be used on each. The reception of drug and placebo will be checked in two cycles and in these two cycles, they will receive every 8 hours for 3 days in the first three days of the menstrual cycle. The first month, non of the groups receive any medication, just answer questionnaires for baseline information. Medicines will be received for 2 months. Finally, the data will be collected at the end of each drug receiving day, with two questionnaires, Visual analogue Scale and Moos Menstrual Questionnaire, and will be analyzed with descriptive and analytical statistical methods by SPSS software.

Entry requirements: having a certain age range with a certain weight and regular and painful menstrual cycles Conditions of non-entry: having underlying and chronic diseases and sensitivity to herbal compounds, menstrual and abdominal-pelvic problems, using contraceptive pills, and having stress and mental problems

The intervention group is 45 patients who take the Anaheal capsule three times a day for three days in two menstrual cycles. The control group is 45 patients who take the placebo capsule three times a day for three days in two menstrual cycles.

Investigating the effectiveness of bromelain extract on primary dysmenorrhea pain

Randomly, a block of size six (with the help of CREATE A RANDOMISATION LIST computer program online tool) will be divided into two equal groups. In fact, 15 blocks of 6 people will be formed, and in each block, three people will be randomly assigned to the first group (bromelain) and three people to the second group (placebo).

In this three-blind randomized clinical trial study, patients receiving Anaheal or placebo are unaware of what drug they will receive. Also, the person (researcher) evaluating the severity and duration of the patients' pain will be unaware of what medicine each patient receives. The person analyzing the statistical data of the study will also be unaware of which group each patient belongs to.