Comparison of anesthetic injection lidocaine with articaine on changes in heart rate ,blood oxygen saturation percentage and blood pressure in Candidate patients for tooth extraction: a Randomized clinical trial

General goal: to compare the effectiveness of injection of lidocaine anesthesia with articaine on heart rate, blood oxygen saturation percentage and blood pressure in patients who are candidates for tooth extraction. functional goal: If the superiority of each is determined, it can be a good guide for dentists to choose an anesthetic agent.

Clinical trial, double blind, phase 4 on 44 people, two parallel groups A block allocation table will be used for randomization

This study will be conducted on patients referred to Gorgan Dental Faculty. First, the patient rests upright for 5 minutes, and to evaluate the dental anxiety of the patients, the questionnaire of Stuttered et al. If the patient's dental anxiety is in the normal range (less than equal to 90), then the patient's heart rate (HR) and blood oxygen saturation (SPO2) were measured by a fingertip pulse oximeter before anesthesia injection. On the index finger of the patient's right hand, the blood pressure is also measured by a digital sphygmomanometer. Then the anesthetic injection is performed by the research associate student. And then the HR and SPO2 values ​​are measured by the pulse oximeter on the same index finger. The blood pressure measurement will be done in the same way.

Inclusion criteria 1) Healthy people between 30 and 50 years old 2) Candidates for extraction of lower jaw teeth Non-entry criteria: 1) People with cardiovascular, renal, respiratory disease, liver failure and hyperthyroidism 2) Pregnant women 3) All diabetic patients 4) People with dental anxiety outside the normal range 5) People who take drugs affecting heart rate

In this study, we have 2 groups, one of which is injected with anesthetic lidocaine and the other with articaine.

heart beat Blood oxygen saturation blood pressure

Block allocation method: People are randomly assigned to articaine (A) and lidocaine (B) groups. Random block method will be used to assign people to groups. For this purpose, all six positions of letters A and B are considered in blocks of four as in the table below. AABB (1) ABAB (3) ABBA (5) BBAA (2) BABA(4) BAAB(6). 11 blocks of 4 are needed to allocate 22 samples in each group (44 people in total). To select 11 blocks first,11 random numbers between 1 and 6 will be generated by repetition (with placement). In this way, a sequence of letters A and B including 44 letters (22 letters A and 22 letters B) will be created.

In this double-blind clinical trial study, all injections will be performed by a trained student (researcher) under the supervision of a maxillofacial surgeon (clinician), and the student will be aware of what kind of anesthetic to use for each patient will inject the anesthetic in opaque syringes to the patients and the patient will not know the type of anesthetic injected. Also, the person (nurse) who will measure the desired values ​​(HR, SPO2 and BP) before and after the injection will not know what kind of anesthetic the patient has received.

After de-identifying individuals, the following information is shared: age gender Blood pressure before and after the injection of each anesthetic drug Blood oxygen saturation percentage before and after injection of each anesthetic drug The heart rate before and after the injection of each of the anesthetic drugs

The access period starts 6 months after the results are published.

Only for researchers working in academic and scientific institutions and students of medical sciences, including medicine, dentistry, pharmacy, etc.

As a study resource for clinical science research

By email to the responsible author of the article resulting from the study Mr. Seyed Alireza Fazeli Alirezafazeli15@gmail.com

If the request is from colleagues and people working in the clinical fields of medical sciences, there will be no process.