A Comparative Study of the Effect of Topical Desmopressin, Phenylephrine and Tranexamic Acid on the Amount of Bleeding and the Field of Vision of the Surgeon During Rhinoplasty Surgery: A Three-blind Clinical Trial Study

Comparison of the Effects of Desmopressin, Phenylephrine and Tranexamic Acid Locally on the Amount of Bleeding and the Field of View of the Surgeon During Rhinoplasty Surgery

Clinical Trial with a Control Group, with Parallel Groups, Three Blinded, Randomized, Phase 3 on 96 Diseases

This Study Will Be Conducted in Hamadan Ba'ath Hospital. This Is a Triple-Blind Study Where the Participants, the Researcher and the Surgeon Are Blinded to the Study. Bleeding Rate Will Be Measured Through Blood Gases and Suction Bottle, and Surgeon's Satisfaction with the Surgical Field Will Be Measured Through Boezaart Scale.

Entry Conditions Include Patients' Age and Standard Laboratory Results. Exit Conditions Include Not Consuming Alcohol, Vitamin E and Aspirin in the Last 1 Week. Also, Patients Should Not Have High Blood Pressure, Brain Diseases, Cardiovascular Diseases, Coagulation Problems, Morbid Obesity, Smoking and Addiction. Patients Who Have a Severe Osteotomy According to the Surgeon, Whose Surgery Takes More Than 2 Hours, and Who Suffer Severe Hypotension During Surgery, Are Excluded from the Study.

The Desmopressin Group Will Receive Two Puffs of Desmex Nasal Spray (40 Micrograms) in Each Nostril 30 Minutes Before Surgery. Tranexamic Acid Group, We Will Break One Tranexip 500 Milligram (Mg) Ampoule and Dip Two 10 Centimeter (Cm) Tampons in It and Place It Inside Each Nostril. for Each Person, Phenylephrine Group, 40 Drops of 0.25% Phenylephrine Are Poured on 2 Tampons of 10 Cm and We Place the Soaked Tampon into Each Nostril. The Control Group Will Receive Two 10 Cm Tampons Soaked in 0.9% Normal Saline in Each Nostril.

Reduction of bleeding during surgery followed by reduction of swelling and ecchymosis after surgery. Surgeon's satisfaction with the surgical field

Patients are Divided by the Method of Eight Random Blocks, which will be Randomly Assigned to One of Four Groups A, B, C, and D. Randomization was Performed by Means of PASS Software Version 11.

We Introduce to the Participants the Drugs Used in the Study and Tell them that the Purpose of Using these Drugs is to Reduce the Amount of Bleeding During Surgery, which have been Used Alone in Other Studies, but their Effects have not been Compared with each Other Study, We Seek to Compare the Effect of these Drugs and Get Satisfaction from the Participants. The Surgeon who is Present in the Study will not know the Type of Drug Used, and before the Surgeon Enters the Operating Room, the Drug is Used, and Inside the Room, Only the Person who Collects the Data is Aware of the Type of Drug Used. The Researcher is not Responsible for Data Collection and Someone from the Treatment Staff who is Outside the Study is Responsible for this Task. The Data Analyst is Given Information in which the Type of Drugs is not Clear and even the Order of Letters of the Groups is Changed.