Effect of High-Definition transcranial Direct Current Stimulation with delta wave on clinical symptoms, salivary cortisol and serum BDNF level of patients with Post Traumatic Stressor Disorder(PTSD)

Evaluation of the effect of high-definition transcranial direct current stimulation with delta wave on clinical symptoms, salivary cortisol and serum BDNF level of patients with Post Traumatic Stressor Disorder(PTSD)

A concealed, randomized, blinded, sham controlled clinical trial with a parallel group design of 40 patients; Simple randomization method is used. To randomize people in groups, the following command code was given in Kotlin programming language. val randomValues ​​= List(40) { Random.nextInt(1, 3) } println(randomValues) Then, the following output was obtained, which includes the random order of entry of people in groups one and two. [1, 2, 2, 2, 1, 2, 1, 2, 2, 2, 1, 1, 2, 1, 1, 1, 2, 2, 1, 1, 1, 2, 2, 1, 2 , 2, 1, 2, 2, 1, 2, 2, 1, 1, 1, 2, 1, 1, 1, 1] Based on this, twenty people are in group one and twenty people are in group two, and for each new person entering, according to this arrangement, people are assigned to group one or two..

This trial is A concealed, randomized, blinded, sham controlled clinical trial with a parallel group design of 40 patients referred to Janat psychiatry hospital of Shiraz or Baghiatollah Hospital of Tehran from August of 2024

Patients referred to the center at the mentioned timeline which have the DSM-5or PCL-5 criteria and have been stable with no recent history of drug abuse in the last 2 weeks and doesn't have any contraindication for HD-tDCS

Patients are randomly classified into 2 groups of 20, one with sham stimulation and the other with real one

Making a protocol for treatment of the patients with PTSD specially for war veterans; Using non aggressive methods like HD-tDCS for their treatment

Patients are randomly diveded into 2 groups of fake or real stimulation, simple randomization method is used.To randomize people in groups, the following command code was given in Kotlin programming language. val randomValues ​​= List(40) { Random.nextInt(1, 3) } println(randomValues) Then, the following output was obtained, which includes the random order of entry of people in groups one and two. [1, 2, 2, 2, 1, 2, 1, 2, 2, 2, 1, 1, 2, 1, 1, 1, 2, 2, 1, 1, 1, 2, 2, 1, 2 , 2, 1, 2, 2, 1, 2, 2, 1, 1, 1, 2, 1, 1, 1, 1] Based on this, twenty people are in group one and twenty people are in group two, and for each new person entering, according to this arrangement, people are assigned to group one or two.

In this trial, patients are blinded to the group they are classified into, but they are completely aware of other aspects of the trial. That is, they do not know whether the device is on or off on their head.