The effect of 0.025 % Atropine on the accommodation and vergence indices in students range of age 18 to 25 years old.

Determining the effect of atropine 0.025% on the angle of deviation and indices of accommodation and vergence system in students aged 18 to 25 years.

A controlled, parallel-group, single-blind, randomized, phase 3 clinical trial on 42 individuals aged 18 to 25 years.

Faculty students with age range of 18 to 25 years who meet the study entry and exit criteria and have completed the consent form are included in this study and their examinations are done in the faculty clinic. In the intervention group, 0.025% atropine are poured every night before going to bed at a specific time, and the control group is asked to use artificial tear drops in the same way. In order to blind, atropine drops are poured into artificial tear containers so that people are blind in terms of the type of drop. Visual acuity, refractive error, and all indicators of the accommodation and vergence system will be measured and compared before and one week after the intervention.

Inclusion criteria: person with 18 to 25 years, best corrected visual acuity of 20/20, Normal binocular vision Exclusion criteria: history of eye symptoms caused by close work, diplopia or blurred vision, history of strabismus, amblyopia or pathological eye diseases

This study includes two groups. One group drop 0.025% atropine in each eye every night and is the intervention group, which is supposed to investigate the effect of this drug on all aspects of the vergence and accommodation system. The second group is the control group, who put one drop of artificial tears in each eye every night.

The amount of changes in the amplitude of accommodation , the amount of ocular deviation in far and near

for randomize using randomization programs available on the Internet, the numbers 1 to 42 were randomly assigned to two groups A and B, and the prepared list is as follows. To assign labels A and B to the low-dose Atropine and artificial tear drop intervention group, a coin toss lottery was used, and group B was determined as the intervention group (use of Atropine) and group A was determined as the control group (artificial tears).Since each number is randomly assigned to a group A or B, each person who have inclusion criteria and enters the study is placed in one of the groups according to the randomization table. According to the sample volume, if the drop is determined. If the drop is more than the number included, the ITT (Intention To Treat) method will be used.

After randomizing, the low dose atropine was prepared and poured into the container that it look exactly like artificial tear drops and in this way the participants were blinded to the type of drops used.

All data can be shared after de-identifying sample

Data access period 4 months after publication of results

Researchers in academic and scientific institutions

In order to more closely examine the characteristics of the sample and the effects of the drop and on the indices of the Accommodation and vergence system. Academics and researchers can request to receive data.The requester can perform any analysis on the data, citing its source and obtaining permission to express it in studies or articles. To send a request, it is enough to send an email to Dr. Mirzajani or Ms. Farzaneh Dehghanian.

Farzaneh Dehghanian Nasrabadi fdehghanian1991@gmail.com

By sending an email to Mrs. Farzaneh Dehghanian and mentioning which scientific institute they are working in