Evaluation the anti-inflammatory effects of nebulized heparin in ventilator-induced lung injury

Objective: Evaluation the effect of nebulized heparin in improvement of lung function in patients expected to require prolonged mechanical ventilation. Design: Non-randomized controlled clinical trial. Setting: Mechanically ventilated patients hospitalized at intensive care unit of Alzahra hospital affiliated to Isfahan University of Medical Sciences. Major Inclusion and Exclusion criteria: Patients who require invasive mechanical ventilation for more than 48 hours will be enrolled in the study. If patients receive mechanical ventilation for more than 24 hours prior to enrollment, require mechanical ventilation for more than 48 hours in a previous admission to the ICU during the current hospital admission, allergy to heparin (including any history of heparin-induced thrombocytopenia), a pulmonary hemorrhage in the previous 3 months, uncontrolled bleeding or a significant bleeding disorder, an intracranial hemorrhage in the past 12 months, or an epidural catheter in place or likely to be placed in the next 48 hours and are younger than 18 years old will be excluded. Intervention: Patients in drug group will receive heparin 10000 Iu every 6 hours via nebulization for 5 days. Both groups will receive all other standard treatments. Main outcome measures: the average daily ratio of partial pressure of oxygen to FiO2 (PaO2/FiO2) while the patient remained ventilated during 5 days of treatment.

Isfahan University of Medical Science