Investigating the preventive effect of intranasal dexamethasone in reducing nausea and vomiting after laparoscopic surgery in children

The results of this study may contribute to reducing postoperative complications and hospital costs in children undergoing laparoscopic surger

This study is a randomized, triple-blind, controlled clinical trial.Participants will be randomly assigned to one of the study groups using the Random Allocation software. The random allocation to groups will be carried out by a nurse who is not involved in the study. It is worth mentioning that the injection syringes in both groups are identical in shape and brand, and are labeled with letters A and B to ensure blinding.

The patient, physician, and the data analyst are blinded to the group assignments. This study will be conducted at Imam Hossein Hospital in Isfahan. Patients will be divided into two groups those receiving dexamethasone and those receiving normal saline. The primary outcome will be the occurrence of PONV within the first 24 hours after surgery

Inclusion Criteria 1. Age range between 2 to 15 years. 2. Candidates for laparoscopic herniorrhaphy or varicocelectomy (type of surgery should be limited; gastrointestinal surgeries are excluded). 3. Informed consent from the parents of the patient to participate in the study. 4. ASA classification I & II Non-Inclusion Criteria 1. Patients with motion sickness. 2. Patients with a history of nausea and vomiting post-surger 3. Nasal mucosal disorders such as allergies and polyps 4. Patients who received anti-nausea medications

In the intervention group, children will receive dexamethasone at a dose of 0.15 mg/kg after the induction of anesthesia, while the control group will receive a normal saline solution at the same dose

Reducing the incidence of nausea and vomiting in children undergoing laparoscopic surgery

This clinical trial study will be conducted after obtaining the necessary permits and ethical code, and it will assess the effect of dexamethasone on reducing nausea and vomiting after surgery in children undergoing laparoscopic procedures. These patients will be kept NPO (nothing by mouth) for 6 to 8 hours before entering the operating room. They will be randomly assigned to one of the study groups using the Random Allocation software. The random allocation to groups will be carried out by a nurse who is not involved in the study. In the intervention group, children will receive dexamethasone at a dose of 0.15 mg/kg after the induction of anesthesia, while the control group will receive normal saline at the same dose. It is worth noting that the syringes used in both groups will be identical in shape and brand, marked with letters A and B to ensure blinding. The codes will not be revealed until after data analysis. The patient, evaluating physician, and data analyst will be blinded and unaware of group assignments. After the children enter the operating room, their demographic data, such as age, gender, and ASA score, will be recorded through a checklist.

This clinical trial study will be conducted after obtaining the necessary permits and ethical code, and it will assess the effect of dexamethasone on reducing nausea and vomiting after surgery in children undergoing laparoscopic procedures. These patients will be kept NPO (nothing by mouth) for 6 to 8 hours before entering the operating room. They will be randomly assigned to one of the study groups using the Random Allocation software. The random allocation to groups will be carried out by a nurse who is not involved in the study. In the intervention group, children will receive dexamethasone at a dose of 0.15 mg/kg after the induction of anesthesia, while the control group will receive normal saline at the same dose. It is worth noting that the syringes used in both groups will be identical in shape and brand, marked with letters A and B to ensure blinding. The codes will not be revealed until after data analysis. The patient, evaluating physician, and data analyst will be blinded and unaware of group assignments. After the children enter the operating room, their demographic data, such as age, gender, and ASA score, will be recorded through a checklist. This study is a randomized, triple-blind, controlled clinical trial.

There is no additional information available.

This clinical trial study will be conducted after obtaining the necessary permits and ethical code, and it will assess the effect of dexamethasone on reducing nausea and vomiting after surgery in children undergoing laparoscopic procedures. These patients will be kept NPO (nothing by mouth) for 6 to 8 hours before entering the operating room. They will be randomly assigned to one of the study groups using the Random Allocation software. The random allocation to groups will be carried out by a nurse who is not involved in the study. In the intervention group, children will receive dexamethasone at a dose of 0.15 mg/kg after the induction of anesthesia, while the control group will receive normal saline at the same dose. It is worth noting that the syringes used in both groups will be identical in shape and brand, marked with letters A and B to ensure blinding. The codes will not be revealed until after data analysis. The patient, evaluating physician, and data analyst will be blinded and unaware of group assignments. After the children enter the operating room, their demographic data, such as age, gender, and ASA score, will be recorded through a checklist.

Data collection will begin on September 16, 2024, and will conclude on March 15, 2025. After this date, the results will be accessible.

This study will be accessible to both people in academic and scientific institutions and people in industry

In order to use the data in studies and other works, it is necessary to coordinate with the person in charge of the research And only reading is free for the public

Coordination with the research officer, Dr. Hamidreza Shatabi, or the research affairs of Isfahan University of Medical Sciences

Coordination with the research officer, Dr. Hamidreza Shatabi, or the research affairs of Isfahan University of Medical Sciences(email,phone and…)