The effect of dyspepsia and reflux treatment on the number and severity of migraine headache attacks: a clinical trial study

Determining the effect of dyspepsia and reflux treatment on the number and severity of migraine headaches: a clinical trial study

clinical trial with an intervention group, with a parallel group; Double blind, randomized

This study is conducted in Razi Birjand Hospital, South Khorasan Province. 60 patients with migraine are randomly divided into two intervention or control groups. At the beginning and end of the study,

Our study population is patients with migraine headaches (with the criteria of migraine with the indication of prophylactic treatment as described below) who referred to the neurology clinic of Razi Hospital in 1402, who also have dyspepsia, peptic ulcer, and gastroesophageal reflux disease. . Inclusion criteria include: having informed consent, age 18 to 60 years, and exclusion criteria include: history of drug use, psychotic disorder, contraindications to drug prescription, under treatment for constipation, under treatment for peptic ulcer, and drug sensitivity to drugs related to treatment. It was digestive disorders.

The intervention groups are as follows: Group 1: recipients of routine migraine medications (suitable to each person's condition) and group 2: recipients of routine migraine medications + medications to resolve patients' digestive problems, such as peptic ulcer medications, PPI (pantoprazole 40 per day) Fasting in the morning), anti-reflux and necessary recommendations to prevent reflux will be included.

The duration of headache, intensity of headache and number of headaches before the intervention and 2, 4 and 6 months after the intervention are evaluated.

Placement of people in each group by a simple random block method in one of two groups 1: recipients of routine migraine medications (suitable to the conditions of each person) and group 2: recipients of routine migraine medications + medications to resolve patients' digestive problems such as Related to peptic ulcer, PPI (pantoprazole 40 every morning fasting), anti-reflux and necessary recommendations to prevent reflux will be included. For randomization, blocks of four were created as RDRD, DRDR, RDDR, DRRD, DDRR, RRDD and kept in a sealed envelope. Then one of the envelopes will be randomly removed from the first patient who came and the placement of the first 4 patients will be determined. Then randomization is done for other patients in this way.

Outcome assessor: The study leader (neurology assistant) asks the patients about the frequency, intensity and duration of headache before and after the intervention and records it in a checklist. In order to check the severity of the headache, the patients are asked to rate their headache from 0 to 10. Data analyst: the data is coded and according to groups 1 and 2 in the Excel file, it is provided to the data analyst, and after analyzing the results, it is collected from him by the neurology assistant in the form of groups 1 and 2.