Effect of Topical Pistacia Atlantica Oil on some Clinical of Knee Osteoarthritis: a Randomized and Double Blind Clinical Trial

Determining the local effect of caraway oil on some clinical symptoms of knee osteoarthritis: a double-blind clinical trial study.

The study is a parallel- groups, randomized, double-blind, and controlled clinical trial. Phase 3 on 50 patients in three groups.

A clinical trial will be conducted in 2019 on osteoarthritis patients referred to the rheumatology clinic in Rafsanjan. Diagnosis is made by the American College of Rheumatology. The pain level of the patients will be evaluated at the beginning and end of the study with the help of a visual analogue scale (VAS). This criterion is a 10 cm ruler that the patient is asked to indicate the intensity of his pain from 0 to 10. WOMAC (Western Ontario and Mc Master) criteria will be used to check the performance of patients.

All patients with osteoarthritis between the ages of 50-70. Inclusion: The diagnosis of knee osteoarthritis is based on the the American College of Rheumatology. Average knee pain during 24 hours based on the linear-visual pain scale (VAS) 4-7 cm. Exclusion: Patients suffering from inflammatory diseases and cancer, liver or kidney failure, Taking oral corticosteroids during the last 4 weeks, corticosteroids injection in the last 6 months. fever, Consuming medicinal plants , Allergy to the Pistacia Atlantica, unwillingness to continue in the study, Failure to comply with the study protocol, Side effects may be caused by Pistacia Atlantica by oil.

Intervention group A: Group A will use piroxicam gel topically. Intervention group B: Group B will use topical Pistacia Atlantica oil to relieve pain. Control group: In group C, paraffin will be used for placebo and to compare their effects

Pain and status of osteoarthritis range of motion, morning dryness and physical function

In this study, in order to reduce bias and increase the reliability of the results, patients were assigned to three groups using a table of random numbers. In this way, the researcher first considered the direction of reading the numbers as a left-to-right convention. Then he assigned numbers 00-30 to group A, numbers 31-60 to group B, and numbers 61-90 to group C. Then the researcher put his hand on one of the numbers and recorded the numbers from left to right and assigned them to different groups. To hide the random allocation (allocation concealment), drugs and placebo were placed in the same packages and coded as A, B, and C. In the randomization process, the person involved in creating the randomization plan was separate from other researchers, to reduce possible bias.

Before starting the study, the drugs will be placed in the same packages by someone other than the researcher and coded as A, B, and C. Medicines are prescribed by a rheumatology specialist in the form of medicine A or B or C and the medicine is delivered by another person. The evaluation of clinical symptoms is done by the internal resident, who does not know the type of medicine used by each person, and based on the relevant protocol (which is explained below).

There is no further information