Autologous Conditioned Serum's impact on maxillofacial lesion healing

Assessing how well processed autologous serum works to mend wounds in the face and jaw

Ten patients participated in a phase one, double-blind, simple randomization clinical study with a control group and an intervention group. The "Random Allocation Rule" method was used for randomization.

After obtaining informed consent, ten patients with mandibular bone fractures who were referred to the Tabriz University of Medical Sciences Faculty of Dentistry clinic were split into two groups: one group received processed autologous serum, while the other group received treatments. The patients were chosen based on the pertinent criteria. They will be split up and given the routine. Then, in order to create processed autologous serum, 20 cc of blood from the intervention group will be extracted from the cubital vein and collected in a specialized Ertokin syringe. One milliliter of the prepared serum is injected into the target region three times on days 0, 3, and 7. The control group receives standard care. Using histology, histomorphometry, and tomography techniques, the healing of the formed bone lesions will be assessed one, three, and six months later.

Enter: Having trouble chewing food Tooth misalignment Teeth falling out or coming loose Not enter: Individuals with underlying medical conditions Individuals having issues with coagulation

Intervention group: group that gets autologous serum that has been treated Control group: The control group, which will get standard care

The efficiency of processed autologous serum in treating lesions on the face and jaw

Initially, the sample size was determined to be 10 individuals with mandibular bone fractures who satisfied our inclusion requirements. The "Random Allocation Law" technique was used to the randomization process, writing the numbers 1 through 10 on the cards. The control group, which did not receive any therapy (other from the standard therapies), was assigned odd numbers, whereas the treatment group was assigned even numbers. By using this approach, the number of participants allocated to each group at the conclusion of the research is balanced. Each card was put in an opaque, sealed envelope to disguise the random distribution.

All participants in this research are not aware of their study group assignment, nor are those in charge of data collecting and analysis. This implies that participants are unaware of whether they are in the control group, which only receives regular therapies, or the intervention group, which receives autologous serum therapy in addition to normal treatments. All patients get standard restorative therapies, including antibiotics, steroidal anti-inflammatory medicines, and analgesics like acetaminophen or ibuprofen, and there is no placebo employed in the trial. They do not know whether they are in the control group or the intervention group, but only the intervention group gets autologous serum in addition to standard therapy. Additionally, those in charge of data collection and analysis are unaware of whether the data they gather and examine is from the intervention group or the control group. Prior to the study's randomization, participants were notified, and their informed permission was acquired. It should be mentioned that the individuals in charge of gathering and analyzing the data are not involved in any other aspects of this research.