The effect of a course of resistance training with calcium plus vitamin D supplementation on the level of growth factor beta 1(TGF-β1) and high-sensitive C reactive protein (hs-CRP)

The aim of the present study was to investigate the protective effect of training combined with calcium and vitamin D supplementation on inflammatory factors in elderly men.

A controlled clinical trial with parallel groups (supplement and training, placebo and training and control), double-blind, on 45 elderly people. A random number table was used for randomization.

After selecting 45 eligible elderly men who were referred to health centers in Zabol city and grouping the individuals, for four weeks, the exercise groups will follow three exercise sessions with an intensity of 65 to 75% of one repetition maximum per week, and the supplement groups will follow a program of one 1000 mg calcium tablet per day along with one 50,000 international unit vitamin D capsule per week. For double-blinding, before the start of the study, the packages containing the supplement and placebo will be marked by a person other than the researcher, and the supplement and placebo will be consumed under the supervision of the same person.

Age range: 60-70 years, BMI between 18.5 and 25 kg/m2, having a general level of physical and mental health, inactive lifestyle. Exclusion criteria: using walking aids, using medication in the previous 6 months, having cardiovascular diseases

Intervention group 1: Training with supplement, one 1000 mg calcium tablet per day along with one 50,000 IU vitamin D capsule per week and resistance squat exercises 3 sessions per week. Intervention group 2: Training with placebo, one 1000 mg placebo tablet per day along with one 50,000 IU placebo capsule per week and resistance squat exercises 3 sessions per week. Control group: Following daily activities without supplement and exercise

growth factor beta 1 and high-sensitive C reactive protein

Number randomization was performed using Random Allocation software using permutation block method. The numbers are sorted into three blocks and assigned to the codes A, B and C. That the codes A, B, and C are unknown for the researcher.

Participants in the supplement groups will consume 1000 mg of calcium per day along with 50,000 IU of vitamin D per week, while those in the placebo groups will be prescribed starch tablets and capsules in the same number and frequency as the supplement group. Before the study begins, the containers containing the supplement and placebo will be marked by a person other than the researcher to ensure that neither the researcher nor the participants know which capsules they are receiving. Supplement and placebo intake was done under the supervision of the same person.

Participants' information will be made available to other researchers after being de-identified

After the publication of the final research report.

Researchers

Citing the findings by citing the source

Those interested in more information can contact the following email and address: Postal address: University of Zabol Email: elhamghasemi@uoz.ac.ir

Those interested in more information can contact the following email and address: Postal address: University of Zabol Email: elhamghasemi@uoz.ac.ir