Investigating the effect of high dose intravenous vitamin C on the serum levels of liver enzymes in patients with hepatic toxicity hospitalized due to opiates.

The Effect of Intravenous Vitamin C on Serum Levels of Hepatic Enzymes in patients Poisoned by Opiates Hospitalized.

The clinical trial consisted of vitamin C and randomized placebo group with triple-blind placebo. It is performed on 128 patients with simple randomized.

This project is being carried out in the case of poisoned patients with liver damage in Loghman Hakim Hospital in Tehran in a randomized three-blind and sequentially numbered Sealed Opaque Envelops (SNOSE).

Informed written consent to enter the investigation on behalf of the patient or legal guardian. Age between 18 and 65 years old. Any underlying chronic disease such as liver and kidney disease, autoimmunity or cancers. No acute kidney injury. No G6PD Defficiency. Opioid poisoners hospitalized in Loghman Hospital in 2024-2025 whose liver enzyme levels are higher than 5 times normal. Exclusion criteria: In case of oxalate nephropathy or hypernatermia during the treatment procedure, these patients will be excluded from the study.

128 patients who are referred to Loqman Hospital due to poisoning, if they have Inclusion criteria are included in this study. Patients will be randomly divided into two groups of 64 people as the group receiving intravenous vitamin C or pelcebo.

To determine the efficacy of vitamin C doses in the treatment of severe liver damage caused by opium abuse in humans.

Patients were randomly divided into two groups of 64 patients given groups: The groups receiving intravenous vitamin C and the other one placebo . This division will be done by creating a random sequence generation in the form of simple randomization and by preparing and removing the shuffling cards. So that a number of cards will be prepared as the first group and the same number of cards will be prepared for the next groups. Then, by pressing them, a card is taken out and its allocation is recorded, and that card is returned to the sum of the other cards Found. Concealment of random allocation by placing the aforementioned cards inside the envelope Opaque Sealed Sealed Envelops (SNOSE)Performed It will be done. People from the research team who are responsible for the above steps enter the other stages of the investigation, especially the examination of people from the point of view of dependent variables, they will not be.

Patients were randomly divided into two groups of 64 patients given: The groups receiving intravenous vitamin C and the other placebo. This division will be done by creating a random sequence generation in the form of simple randomization and by preparing and removing the shuffling cards. So that a number of cards will be prepared as the first group and the same number of cards will be prepared for the next groups. Then, by pressing them, a card is taken out and its allocation is recorded, and that card is returned to the sum of the other cards Found. Concealment of random allocation by placing the aforementioned cards inside the envelope Opaque Sealed Sealed Envelops Performed It will be done. People from the research team who are responsible for the above steps enter the other stages of the investigation, especially the examination of people from the point of view of dependent variables, they will not be.