Clinical trial assessment of intermittent and continuous infusion dose of N-acetylcysteine on oxidative stress levels and total antioxidant capacity of the body in septic patients admitted to the ICU

Propose: Assessment of intermittent and continuous infusion dose of N-acetylcysteine (NAC) on oxidative stress levels and total antioxidant capacity of the body in septic patients admitted to the ICU. This study is prospective, randomize, single blind and clinical trial, 60 patients were randomly divided in three groups with using a random number table(the patient and nurse were blind about the drug). Intervention group 1 received 25 mg/kg intravenous bolus N-acetyl cysteine (NAC) at the beginning and then 25 mg/kg every 8 hours for 24 hours (total 100 mg/kg during the 24 hours). Intervention group 2 received 25 mg/kg intravenous bolus N-acetyl cysteine (NAC) at the beginning and then 75 mg/kg intravenous NAC as a continuous infusion over 24 hours (total 100 mg). In the placebo group received 100 mg/kg saline. Inclusion criteria: patients with systemic inflammatory response syndrome, infection (sepsis) admitted to the ICU. Exclusion criteria: lack of patient consent to participate in the study; Taking any supplements such as vitamins with antioxidant properties known as C, E, A, trace elements zinc, manganese, selenium, and NAC before entering the study; NAC drug contraindications for any reason. Primary outcome: total antioxidant capacity and the level of Lipid peroxide serum. To measure the total antioxidant capacity of serum and level of Lipid peroxide serum was used Cayman company kits.

Vice Chancellor for Research Mashhad University of Medical Sciences