History
# Registration date Revision Id
3 2023-07-13, 1402/04/22 271344
2 2020-05-30, 1399/03/10 136653
1 2020-05-14, 1399/02/25 134297
Changes made to previous revision
  • Help:

    Red color represents old content. It may be empty showing addition in the new version.
    Green color represents new content. It may be empty showing deletion in the new version.

    Inline Side by side
    Added new contents, deleted old contents, contents that are not changed.
    New table contents New table contents
    Old table contents Old table contents
    Unchanged contents Unchanged contents
    Added new contents, contents that are not changed.
    Deleted old contents, contents that are not changed.
    Old table contents Old table contents
    Unchanged contents Unchanged contents
    New table contents New table contents
    Unchanged contents Unchanged contents
  • Protocol summary

    A randomized clinical trial, with parallel groups, phase 3، without blindness that, 242 patients randomly divided into two groups of 121 subjects with block sizes of 4 and 6.
    A randomized clinical trial, with parallel groups, phase 3، double blind that 120 patients randomly divided into two groups of 60 subjects with block sizes of 4 and 6.
    کارآزمایی بالینی، با گروه های موازی، بدون کورسازی،فاز سه، تصادفی شده که 242 بیمار با اندازه بلوک های 4 و 6 تایی بطور تصادفی به دو گروه 121 نفر تخصیص داده شدند.
    کارآزمایی بالینی، با گروه های موازی، دو سو کور، فاز سه، تصادفی شده که 120بیمار با اندازه بلوک های 4 و 6 تایی بطور تصادفی به دو گروه 60 نفر تخصیص داده شدند.
    Patients referred to Imam Sari hospitals for cesarean section, randomly divided into two Intervention groups with block sizes of 4 and. Then they were assessed for signs and symptoms of surgical-site infection as the primary outcome.
    Patients referred to Imam Sari hospitals for cesarean section, randomly divided into two groups with block sizes of 4 and. Then they were assessed for signs and symptoms of surgical-site infection as the primary outcome.
    بیمارانی که جهت انجام زایمان سزارین به بیمارستان امام ساری مراجعه نمودند با استفاده از بلوک های بلوک های 4 و 6 تایی بطور تصادفی به دو گروه مداخله تقسیم شدند. سپس این دو گروه به لحاظ بروز عفونت زخم و بستری مجدد به دلیل عفونت زخم به مدت یک ماه پیگیری شده و میزان بروز عفونت در مدت یک ماه بعد از عمل و نیاز به بستری مجدد در آنها مورد ارزیابی قرار خواهد گرفت.
    بیمارانی که جهت انجام زایمان سزارین به بیمارستان امام ساری مراجعه نمودند با استفاده از بلوک های بلوک های 4 و 6 تایی بطور تصادفی به دو گروه تقسیم شدند. سپس این دو گروه به لحاظ بروز عفونت زخم و بستری مجدد به دلیل عفونت زخم به مدت یک ماه پیگیری شده و میزان بروز عفونت در مدت یک ماه بعد از عمل و نیاز به بستری مجدد در آنها مورد ارزیابی قرار خواهد گرفت.
    Inclusion criteria: cesarean section surgery less than 40 minutes and Pfannenstiel incision. Exclusion Criteria: extreme obesity (>100 kg), Immunodeficiency, hypertension and diabetes mellitus.
    Inclusion criteria: age 18 to 40 years, gestational age of early term (37 to 38 weeks and 6 days) and full term (39 to 40 weeks and 6 days), elective admission, having a live fetus and mental health of the mother, Pfannenstiel incision. Exclusion Criteria: Patients with known infections before surgery, underlying disorders such as diabetes and blood pressure, immune system deficiency diseases, history of taking drugs that weaken or strengthen the immune system, various cancers, coagulation disorders, malnutrition, and smoking and drug use and people with surgical wound infection in previous cesarean section.
    معیارهای ورود:زایمان سزارین کمتر از 40 دقیقه و انسزیون به شکل فانشتیل معیارهای خروج: چاقی مفرط (وزن بالای 100 کیلوگرم)، نقص ایمنی، دیابت و فشارخون.
    معیارهای ورود:سن 18 تا 40 سال، سن بارداری ترم زودرس (37 تا 38 هفته و 6 روز) و ترم کامل (39 تا 40 هفته و 6 روز)، بستری الکتیو، داشتن جنین زنده و سلامت روانی، انسزیون به شکل فانشتیل معیارهای خروج: بیماران دارای عفونت شناخته شده قبل از جراحی، اختلالات زمینه ای چون دیابت و فشارخون، ابتلا به بیماری های نقص سیستم ایمنی، سابقه مصرف داروهای تضعیف کننده و یا تقویت کننده سیستم ایمنی، انواع کانسرها، اختلالات انعقادی، سوتغذیه و مصرف سیگار و مواد مخدر و افراد دارای عفونت زخم جراحی در سزارین قبلی
    Intervention group: The wounds of patients were irrigated with 300cc normal saline plus 80 mg gentamicin before closing the wound. Control group: The wounds of patients were irrigated with the 300 cc normal saline before closing the wound.
    Intervention group: The wounds of patients were irrigated with 100cc normal saline plus 80 mg gentamicin before closing the wound. Control group: The wounds of patients were irrigated with the 100 cc normal saline before closing the wound.
    گروه مداخله: شستشوی زخم قبل از بستن برش جراحی با 80 میلی گرم جنتامایسین و 300 سی سی نرمال سالین گروه کنترل: شستشوی زخم جراحی قبل از بستن آن با 300 سی سی نرمال سالین
    گروه مداخله: شستشوی زخم قبل از بستن برش جراحی با 80 میلی گرم جنتامایسین و 100 سی سی نرمال سالین گروه کنترل: شستشوی زخم جراحی قبل از بستن آن با 100 سی سی نرمال سالین
  • General information

    empty
    18
    empty
    Year
    Yes
    No
    empty
    40
    empty
    Year
    Yes
    No
    Male
    Female
    Not blinded
    Double blinded
    1
    1
    242
    120
    1733-01-20, 1111/11/01
    2020-08-22, 1399/06/01
    1743-03-21, 1122/01/01
    2021-08-23, 1400/06/01
    empty
    Due to the spread of covid-19 and the reduction of elective surgeries, therefore; The researcher decided to announce the change in the sample size and update the recorded information in this scientific database.
    empty
    با توجه به شیوع کووید-19 و کاهش اعمال جراحی الکتیو، بنابراین؛ محقق بر آن گشت تا تغییر در حجم نمونه را اعلام و اطلاعات ثبت شده را در این پایگاه علمی به روز رسانی نماید.
    cesarean section surgery less than 40 minutes
    Pfannenstiel incision
    Gestational age of early and full term
    Elective admission
    Having a live fetus
    Mother's mental health
    Pfannenstiel incision
    زایمان سزارین کمتر از 40 دقیقه
    انسزیون به شکل فانشتیل
    سن بارداری ترم زودرس و ترم کامل
    بستری الکتیو
    داشتن جنین زنده
    سلامت روانی مادر
    برش فاننشتایل
    Women with extreme obesity (>100 kg)
    Immunodeficiency
    Diabetes mellitus
    Hypertension
    Patients with known infection before surgery
    Having underlying diseases (diabetes, blood pressure, types of cancers)
    Patients with immune system deficiency
    Coagulation disorders
    Malnutrition
    Smoking and drug use
    People with a history of surgical wound infection in a previous cesarean section
    زنان با چاقی مفرط (وزن بالای 100 کیلوگرم)
    نقص ایمنی
    دیابت
    فشارخون
    بیماران دارای عفونت شناخته شده قبل از جراحی
    داشتن بیماریهای زمینه ای(دیابت، فشارخون، انواع سرطان ها)
    بیماران با نقص سیستم ایمنی
    سابقه مصرف داروهای تضعیف کنننده یا تقویت کننده سیستم ایمنی
    اختلالات انعقادی
    سوتغذیه
    مصرف سیگار یا مواد مخدر
    افراد با سابقه ابتلا به عفونت زخم جراحی در سزارین قبلی
    Patients were randomly divided into two groups of 121 subjects with four and six blocks and an allocation ratio of 1:1. Participants allocation sequence in two groups performed with a Randomizer software. Opaque sealed sequentially numbered envelops used for allocation concealment
    Patients were randomly divided into two groups of 60 subjects with four and six blocks and an allocation ratio of 1:1. Participants allocation sequence in two groups performed with a Randomizer software. Opaque sealed sequentially numbered envelops used for allocation concealment
    بیماران با استفاده از بلوک های 4 و 6 تایی و نسبت 1:1 بطور تصادفی به دو گروه 121 نفر تخصیص داده شدند. توالی تخصیص تصادفی بیماران در دو گروه با استفاده از نرم افزارRandomizer انجام گرفت. از پاکت های مات پشت سرهم شماره گذاری شده برای پنهان سازی تخصیص استفاده شد.
    بیماران با استفاده از بلوک های 4 و 6 تایی و نسبت 1:1 بطور تصادفی به دو گروه 60 نفر تخصیص داده شدند. توالی تخصیص تصادفی بیماران در دو گروه با استفاده از نرم افزارRandomizer انجام گرفت. از پاکت های مات پشت سرهم شماره گذاری شده برای پنهان سازی تخصیص استفاده شد.
    Participating patients and the surgeon did not know about receiving subcutaneous gentamicin.
    بیماران شرکت کننده و جراح از دریافت جنتامایسین زیرجلدی اطلاعی نداشتند.
  • Primary outcomes

    #1
    third and tenth day of the operation
    The first day after surgery and the tenth and thirtieth day
    روز سوم و روز دهم بعد از عمل
    روز اول بعد از جراحی و روز دهم و سی ام بعد از عمل
    #2
    third and tenth day of the operation
    The first day after surgery and the tenth and thirtieth day
    روز سوم و دهم بعد از عمل
    روز اول بعد از جراحی و روز دهم و سی ام
  • Secondary outcomes

    #1
    empty
    Pain in the operation area
    empty
    درد ناحیه عمل
    empty
    The first day after surgery, the tenth day and the thirtieth day
    empty
    روز اول بعد از جراحی، روز دهم و روز سی ام
    empty
    Visual Analogue Scale
    empty
    مقیاس دیداری شدت درد
  • Intervention groups

    #1
    Intervention group: The wounds of patients were irrigated with 300cc normal saline plus 80 mg gentamicin (Exir Pharmaceutical Company) before closing the wound
    Intervention group: The wounds of patients were irrigated with 100 cc normal saline plus 80 mg gentamicin (Exir Pharmaceutical Company) before closing the wound
    گروه مداخله: شستشوی زخم قبل از بستن برش جراحی با 80 میلی گرم جنتامایسین( شرکت داروسازی اکسیر) و 300 سی سی نرمال سالین
    گروه مداخله: شستشوی زخم قبل از بستن برش جراحی با 80 میلی گرم جنتامایسین( شرکت داروسازی اکسیر) و 100سی سی نرمال سالین
    #2
    Control group: The wounds of patients were irrigated with the 300 cc normal saline before closing the wound.
    Control group: The wounds of patients were irrigated with the 100 cc normal saline before closing the wound.
    گروه کنترل: شستشوی زخم جراحی قبل از بستن آن با 300 سی سی نرمال سالین
    گروه کنترل: شستشوی زخم جراحی قبل از بستن آن با 100سی سی نرمال سالین

Protocol summary

Study aim
The effect of using gentamicin in subcutaneous tissue, before skin suturing at cesarean section infection
Design
A randomized clinical trial, with parallel groups, phase 3، double blind that 120 patients randomly divided into two groups of 60 subjects with block sizes of 4 and 6.
Settings and conduct
Patients referred to Imam Sari hospitals for cesarean section, randomly divided into two groups with block sizes of 4 and. Then they were assessed for signs and symptoms of surgical-site infection as the primary outcome.
Participants/Inclusion and exclusion criteria
Inclusion criteria: age 18 to 40 years, gestational age of early term (37 to 38 weeks and 6 days) and full term (39 to 40 weeks and 6 days), elective admission, having a live fetus and mental health of the mother, Pfannenstiel incision. Exclusion Criteria: Patients with known infections before surgery, underlying disorders such as diabetes and blood pressure, immune system deficiency diseases, history of taking drugs that weaken or strengthen the immune system, various cancers, coagulation disorders, malnutrition, and smoking and drug use and people with surgical wound infection in previous cesarean section.
Intervention groups
Intervention group: The wounds of patients were irrigated with 100cc normal saline plus 80 mg gentamicin before closing the wound. Control group: The wounds of patients were irrigated with the 100 cc normal saline before closing the wound.
Main outcome variables
infection

General information

Reason for update
Due to the spread of covid-19 and the reduction of elective surgeries, therefore; The researcher decided to announce the change in the sample size and update the recorded information in this scientific database.
Acronym
IRCT registration information
IRCT registration number: IRCT20200126046261N1
Registration date: 2020-05-14, 1399/02/25
Registration timing: prospective

Last update: 2023-07-13, 1402/04/22
Update count: 2
Registration date
2020-05-14, 1399/02/25
Registrant information
Name
معصومه Masoomeh
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 11 3325 7230
Email address
zakeri.m@mazums.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2020-08-22, 1399/06/01
Expected recruitment end date
2021-08-23, 1400/06/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effect of using Gentamicin in subcutaneous tissue, before skin suturing at cesarean section infection
Public title
The effect of Gentamicin at cesarean section infection
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria:
Gestational age of early and full term Elective admission Having a live fetus Mother's mental health Pfannenstiel incision
Exclusion criteria:
Patients with known infection before surgery Having underlying diseases (diabetes, blood pressure, types of cancers) Patients with immune system deficiency Coagulation disorders Malnutrition Smoking and drug use People with a history of surgical wound infection in a previous cesarean section
Age
From 18 years old to 40 years old
Gender
Female
Phase
3
Groups that have been masked
  • Participant
  • Care provider
Sample size
Target sample size: 120
Randomization (investigator's opinion)
Randomized
Randomization description
Patients were randomly divided into two groups of 60 subjects with four and six blocks and an allocation ratio of 1:1. Participants allocation sequence in two groups performed with a Randomizer software. Opaque sealed sequentially numbered envelops used for allocation concealment
Blinding (investigator's opinion)
Double blinded
Blinding description
Participating patients and the surgeon did not know about receiving subcutaneous gentamicin.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Mazandaran University Of Medical Sciences
Street address
Vice –Chancellor for Research of Mazandaran University of Medical Sciences, Moalem Square
City
Sari
Province
Mazandaran
Postal code
4816715793
Approval date
2020-04-29, 1399/02/10
Ethics committee reference number
IR.MAZUMS.REC.1399.148

Health conditions studied

1

Description of health condition studied
Wound infection
ICD-10 code
O86.0
ICD-10 code description
Infection of obstetric surgical wound

Primary outcomes

1

Description
wound infection
Timepoint
The first day after surgery and the tenth and thirtieth day
Method of measurement
physical examination

2

Description
wound dehiscence
Timepoint
The first day after surgery and the tenth and thirtieth day
Method of measurement
physical examination

Secondary outcomes

1

Description
Pain in the operation area
Timepoint
The first day after surgery, the tenth day and the thirtieth day
Method of measurement
Visual Analogue Scale

Intervention groups

1

Description
Intervention group: The wounds of patients were irrigated with 100 cc normal saline plus 80 mg gentamicin (Exir Pharmaceutical Company) before closing the wound
Category
Prevention

2

Description
Control group: The wounds of patients were irrigated with the 100 cc normal saline before closing the wound.
Category
Prevention

Recruitment centers

1

Recruitment center
Name of recruitment center
Emam Khomeini Hospital
Full name of responsible person
Ebrahim Nasirifar
Street address
Sari, Imam Sq, Amir Mazandarani street
City
Sari
Province
Mazandaran
Postal code
4816633131
Phone
+98 11 3304 4000
Email
enasiri@mazums.ac.ir

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Mazandaran University of Medical Sciences
Full name of responsible person
Aliakbar Hedaiatizadeh
Street address
Vice Chancellor for Research of Mazandaran University of Medical Sciences, Moalem Square, Moalem Street. sari Mazandaran
City
Sari
Province
Mazandaran
Postal code
4817918479
Phone
+98 11 3325 7230
Email
akbar_hedayati@mazums.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Mazandaran University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Mazandaran University of Medical Sciences
Full name of responsible person
Ebrahim nasirifar
Position
Assistant
Latest degree
Ph.D.
Other areas of specialty/work
Traditional Medicine
Street address
Traditonal and complementary research center of Mazandaran University of Medical Scienses
City
Sari
Province
Mazandaran
Postal code
4847116548
Phone
+98 11 3354 3239
Email
enasiri@mazums.ac.ir

Person responsible for scientific inquiries

Contact
Name of organization / entity
Mazandaran University of Medical Sciences
Full name of responsible person
Ebrahim Nasirifar
Position
Assistant
Latest degree
Ph.D.
Other areas of specialty/work
Traditional Medicine
Street address
Traditonal and complementary research center of Mazandaran University of Medical Scienses
City
Sari
Province
Mazandaran
Postal code
4847116548
Phone
+98 11 3354 3239
Email
enasiri@mazums.ac.ir

Person responsible for updating data

Contact
Name of organization / entity
Mazandaran University of Medical Sciences
Full name of responsible person
Ebrahim nasirifar
Position
Assistant
Latest degree
Ph.D.
Other areas of specialty/work
Traditional Medicine
Street address
Traditonal and complementary research center of Mazandaran University of Medical Scienses
City
Sari
Province
Mazandaran
Postal code
4847116548
Phone
+98 11 3354 3239
Email
enasiri@mazums.ac.ir

Sharing plan

Deidentified Individual Participant Data Set (IPD)
No - There is not a plan to make this available
Justification/reason for indecision/not sharing IPD
There is still no plan for its puplish.
Study Protocol
No - There is not a plan to make this available
Statistical Analysis Plan
No - There is not a plan to make this available
Informed Consent Form
No - There is not a plan to make this available
Clinical Study Report
No - There is not a plan to make this available
Analytic Code
No - There is not a plan to make this available
Data Dictionary
No - There is not a plan to make this available
Loading...