Comparison of the effect of platelet rich plasma injection with the combination of platelet rich plasma and vitamin C on partial thickness rotator cuff tears

1) Determining and comparing the average pain intensity in the two groups of platelet-rich plasma (PRP) and normal saline injection with PRP and vitamin C injection before, 1 month after and 3 months after the intervention. 2) Determining and comparing the average range of motion angle in the two groups of PRP and normal saline injection with PRP and vitamin C injection before, 1 month after, and 3 months after the intervention. 3) Determining and comparing the average pain intensity and range of motion angle in two groups of PRP and normal saline injection with PRP and vitamin C injection adjusted according to demographic characteristics before, 1 month after and 3 months after intervention

Clinical trial with a control group, with parallel groups, double-blind, randomized, phase 2 on 110 patients. Simple random tables created by computer were used for randomization.

The ultrasound-guided injection will be performed in the subacromial space during two periods with an interval of 3 weeks. The first group will be treated with 1.5 ml of normal saline + 1.5 ml of PRP and the second group will be treated with 2.5 ml of PRP and 0.5 ml of vitamin C. The process of blinding for the patients and the doctor and the person evaluating the treatment result will be done during the study.

Entry conditions: Patients who, according to the clinical examination of an orthopedic specialist doctor and MRI results, according to Elman's classification system, have partial rotator cuff tears of the 1st and 2nd stage located in supraspinatus. Non-entry conditions: Rotator cuff tears secondary to fracture Prior surgical repair or revision arthroscopy

Patients will be randomly assigned to one of two groups: normal saline + PRP or vitamin C + PRP.

pain intensity score; Range of motion angle score

People will be randomly assigned to two groups of normal saline + platelet-rich plasma and vitamin C + platelet-rich plasma by simple random method and based on simple random tables created by computer.

Despite obtaining informed consent from the participants in the study, these people are unaware of which treatment intervention group they will be placed in. The preparation of platelet-rich plasma (PRP) is performed by a hematologist at the Comprehensive Center for Stem Cells and Regenerative Medicine. He combines the PRP prepared from the patients with normal saline or vitamin C and by writing the names of the patients, he is aware of what type of treatment intervention will be done for each person. In addition, the syringe containing any type of therapeutic combination (normal saline + PRP and vitamin C + PRP) will be labeled as A or B by convention, and the mentioned hematologist is aware of how to mark according to the type of therapeutic intervention. The orthopedic specialist who is responsible for injecting the therapeutic combination is unaware of the type of therapeutic combination and is generally kept blind in the study process. The researcher, who is actually the person who evaluates the treatment outcomes and patients' questionnaires, is also kept blind in the study process. The statistical consultant of the research who is in charge of data analysis is also kept blind in the study process.