The study on the effect of Chammomile(Matricaria chamomilla L.)&Lemon balm (Melissa officinalis L.) syrupe on chest pain and quality of life in patient with cardiac syndrome x

primary aims : determiniation effect of effect of Chammomile & Lemon balm syrupe on chest pain and quality of life in patient with cardiac syndrome x secondary aims: 1. design and manufacture of standard chammomile&Lemon balm syrupe 2. Comparision of changes in chest pain in patient with cardiac syndrome x in interventional group with control group 3.Comparision of changes in quality of life in patient with cardiac syndrome x in interventional group with control group objective aims: provide a potentially effective treatment forcardiac syndrome x

The study is a double-blind clinical trial with two parallel control and intervention groups that has been randomized with Block Randomization. Sample size with 20% probability of dropping samples is two groups of 20 people. The phase of study is phase 3

Conducted study: Tehran heart center How to do a study: A double-blind clinical trial is a randomized blocking study. The target community: patient with cardiac syndrome x study groups: two groups of control and intervention. To the control group, placebo and to the intervention group, the chamomile product - lemon balm (5 cc twice daily) is given.

inclusion criteria: Angina- like chest pain positive exercise stress test angiographically normal epicardial coronary arteries no response to treatments in conventional medicine exclusion criteria: sever Valvular heart disease cardiomyopathy coronary spasm LV dysfunction uncontrolled Diabetes mellitus uncontrolled HTN History of myocardial infarction

interventional group: chammomile-lemonbalm syroup control group: placebod

The overall score of pain in the Seattle angina Questionnaire

Using dual and triple blocks, the randomization sequence is prepared. First, all double blocks such as AABB and triple blocks like AABBAB were developed. Then they were given a score and randomly selected sequences from each of them and sorted in the following order. ABABBABBAABABABBABAABAABBABBAAABABABBABAABBBAABABABABBABAAABABABAB This arrangement will be in 60 envelopes in the same way, and the person responsible for the rendezvous will open the relevant envelope for each person in the study and identify the treatment group.

In this study, patients blinding are treated with placebo, which is similar to the original drug. People who measure heart rate and quality of life in patients are not informed about the patient's treatment group. In the event of any uncommon side effects in patients regardless of treatment group, the patient will be excluded from the study and thus there will be no disturbances in blindness. Medication and placebo will be prepared and coded by the traditional consultant of the pharmaceutical consultant, with maximum apparent similarity in terms of packaging and content (flavor and aroma). This coding for the drug and the placebo is confidential by the pharmaceutical specialist, and the continuous numbers and rows are determined by the four blocks of them and will be delivered without disclosure to the researcher. The researcher and the patient are completely unaware of the content and the researcher will provide patients with a randomized randomized blocking drug and placebo. At the end of the study, the rows of drugs and placebo are aggregated by a pharmaceutical expert and will be provided to the expert statistical analyst by unlocking the codes in two groups A and B.

The total potential data can be shared after being unrecognizable in Excel.

Up to 5 years after printing results

Researchers at the academic and scientific institutes of people who are in the field of drug production can apply for them.

1- Performing the same task on heart disease 2- Animal studies 3. drug production

Scientific Researcher: Dr. Hossein Rezaezadeh, emai:hosseinrezaeizade@gmail.com tel:09127038842

1-At the request of a magazine after the acceptance of the article for arbitration 2. If a researcher or a drug manufacturer wants to do the same, they can use the data if they refer to this study.