Study aim: Determining the effect of ALOVERA spray on the treatment of Diabetic Foot Ulcers Design: A clinical trial with a control group, with parallel, single-blind, randomized groups, will be conducted on 180 patients with DFUs. Block randomization method and https://www.sealedenvelope.com was used to randomize the samples. Settings and conduct: 180 diabetic patients with DFU are selected with the inclusion criteria and will be randomly divided into 3 groups [Control groups, intervention 1 (silver nanoparticles) and intervention 2 (hypochlorous acid] using the randomized block method. Patients will be followed up and treated during 5 sessions as weekly visits. The reduction of bacterial load and wound surface will be measured at the beginning, second week, and at fifth week. Participants/Inclusion and exclusion criteria: Patients with neuropathic and neuroischemic diabetic foot ulcers, patients with Pedis grade 1 and 2 diabetic foot ulcers, patients with Wegener grade 1 to 3 diabetic foot ulcers Intervention groups: Control group: In the weekly visit, the wound will be washed with N/S, then sharp debridement and appropriate dressing will be used. During the week, the patient will wash the wound 3 times and change the dressing. Intervention group 1: In the weekly visit, the wound is washed with N/S and Silvosept spray silver (Chitotech) is used to disinfect the wound, and then sharp debridement and dressing suitable for the patient will be used. Intervention group 2: In the weekly visit, the wound is washed with N/S and ALOVERA spray (Negin Daro Azerbaijan Company) is used to disinfect the wound, and then sharp debridement and then appropriate dressing for the patient will be used. In the intervention groups, the patient will wash, disinfect and change the dressing 3 times in a week. The duration of intervention is 5 weeks. Main outcome variables: Wound area & bacterial load on the wound surface

Study aim: Evaluation of the independent and combined effects of combined training with the approach of ultimate preparation and coffee consumption on blood characteristics of middle-aged men with non-alcoholic fatty liver Design: The clinical trial has three experimental groups and the control group is divided into four groups of 11 randomly, without blinding. Settings and conduct: The method of the present study is quasi-experimental and is performed with a pre-test-post-test design in three experimental groups (combined exercise group, combined exercise-coffee consumption, coffee consumption) and control group. The statistical population is middle-aged men 30-60 with non-alcoholic fatty liver with ultrasound grades 1, 2 and 3, and enzymes (ALT) and (AST) and lipid profile above normal, in Borkhar city of Isfahan. The training protocol is done 3 times a week for 60 minutes. Each session consists of 3 5-part practice sections. Consumption of coffee on a daily basis between 9 am and 11 am and in the afternoon between 3 pm and 5 pm One cup (180 cc) of Robusta coffee is consumed in the form of Turkish coffee. Participants/Inclusion and exclusion criteria: Middle-aged men 30 to 60 Year and conditions of entry: Grade 1, 2 and 3 liver disease, people with high blood lipid profile, people without cardiovascular disease and people without physical disabilities Conditions of non-entry: People with grade 4 fatty liver disease, People with physical disabilities, People with heart failure, People with lung disease Intervention groups: The first intervention, combined exercise, the second intervention of coffee consumption, which received three experimental groups of intervention and the control group did not receive any intervention.. Main outcome variables: Decreased liver grade, enzymes (AST) and (ALT) and blood lipid profile, index (BMI) and increased functional skills

Study aim: َAssessing immunogenicity and safety of human papilloma virus vaccine (quadrivalent, Biosun pharmed Co.) compared to gardasil vaccine (quadrivalent, Merck Co.) in healthy adults aged 15-35 years. Design: Phase 3, randomized, double-blinded, parallel arms, active-controlled clinical trial on 450 healthy volunteers. Settings and conduct: This double-blind (volunteers and outcome assessors) phase 3 trial will be conducted at Tehran hospital in Tehran. After random assignment to receive quadrivalent HPV vaccine (Biosun pharmed or Merck) on days 0, 60 and 180, participants will be followed up for immunogenicity and safety. Participants/Inclusion and exclusion criteria: Inclusion criteria: Age 15-35 years, ability to understand the conduct process of the study and signing the informed consent, general health, not having infection in uterus or genital area, not having fever or acute infectious disease, not having a plan to inject other vaccines in the study period, not using vaginal products or sexual intercourse 48 hours before each visit, Seronegative for Anti HPV 6,11,16,18, Not pregnant, agreement to use contraception method for 7 months. Exclusion criteria: history of abnormal pap smear or biopsy, genital wart, history or HPV infection, prior HPV vaccination, history of any vaccine injection in the preceding 21 days, history of severe allergic reactions to vaccine, receiving immunoglobulins or blood products, chronic diseases, Immunodeficiency, thrombocytopenia or coagulation disorder, history of drug or alcohol abuse, intention for pregnancy in 7 months. Intervention groups: Intervention group: intramuscular injection of 0.5ml of quadrivalent HPV vaccine (Biosun pharmed Co.) in days 0, 60 and 180. Control group: intramuscular injection of 0.5ml of quadrivalent HPV vaccine (Merck Co.) in days 0, 60 and 180. Main outcome variables: Human papilloma virus type 6, 11, 16 and 18 antibody titer, GMT

Study aim: To investigate the effect of canola-Pistacia Atlantica seeds oil (a blend of canola and Pistacia Atlantica seed oils compared with canola–corn oil with TBHQ and canola–corn oil without TBHQ on serum oxidant and antioxidant status markers in patients with metabolic syndrome. Design: Three way randomized cross-over clinical trial Settings and conduct: This study will be conducted at the school of Public health. all three oils will be provided in the same packages labeled by a person not aware of the study objectives. Participants and personnel will be blinded to the intervention oil. Participants/Inclusion and exclusion criteria: Inclusion criteria: Males and females aged 20-50 years and with at least three of 5 metabolic syndrome conditions. Exclusion criteria: history of cardiovascular diseases, diabetes, cancer, liver, kidney, gastrointestinal disease, changing blood glucose and lipid profile control medications in previous 3 months, taking corticosteroids, androgens, phenytoin, erythromycin, hemostatic regulators (other than Asprin), and gastrointestinal medication in last 30 days, alcohol consumption, pregnancy, giving birth in last 12 months, smoking, omega-3 supplement use >1 g/day, severe weight change in previous 3 months, not willing to enter or follow the study protocol Intervention groups: Each intervention period (phase) will last 8 weeks. The participants will receive canola-Pistacia Atlantica seed oil, canola–corn oil (with TBHQ), and canola–corn oil (without TBHQ) in each intervention period. Intervention periods will be separated with 4 weeks of washout periods (sunflower oil will be provided). Main outcome variables: Serum total antioxidant capacity, Total oxidant capacity, malondialdehyde, myeloperoxidase , superoxide dismutase , catalase , glutathione peroxidase, glutathione reductase, and nitric oxide levels

Study aim: The impact of Urinary incontinence rehabilitation Intervention on self esteem and quality of life in women with neurogenic bladder Design: Quasi experimental study with available samples by one group method before and after with a sample size of 35 people Settings and conduct: 1) Development and approval of interventions 2) Sampling of 35 women with neurogenic bladder hospitalized in multiple sclerosis and spinal cord injuries and strokes of Rofeideh Rehabilitation Hospital 3) Explain the goals and fill out the informed and pre test consent form 4) Perform a 2 dimensional intervention including clean intermittent catheterization, behavioral therapy In 12 sessions of 30 minutes in six weeks, which are 7 sessions in the first week and then weekly 5) Post test Participants/Inclusion and exclusion criteria: Inclusion: Clean intermittent catheterization Literacy body mass index ؛ Non inclusion: Cervical spinal cord injuries Alcohol and drug Acute depressive disorder Drugs affecting urinary incontinence Diuretics Active urinary tract infection Gynecological surgeries Being pregnant History of cesarean section or normal delivery in the last 6 months Pelvic floor muscle prolapse Intervention groups: 1) Development and approval of interventions 2) Sampling of 35 women with neurogenic bladder hospitalized in multiple sclerosis wards and spinal cord injuries and strokes of Rofeideh Rehabilitation Hospital by available sampling method based on inclusion and exclusion criteria within a period of one month 3) Explain the goals and fill out the informed and pretest consent form 4) Perform a 2 dimensional intervention including clean intermittent catheterization, behavioral therapy (determining the time of urination, delaying urination and adjusting diet and medication) in 12 sessions in six weeks 5)Post test Main outcome variables: Improving quality of life and self esteem in urinary incontinence

Study aim: Determining the effectiveness of midwifery counseling with an acceptance and commitment approach on body image and breastfeeding self-efficacy Design: The clinical trial is a parallel type with two arms, one is the intervention group and the other is the control group. It is performed on 90 pregnant women who are eligible for the study. Block method with a volume of 4 to 45 people in the control group and 45 people in the intervention group are allocated. Settings and conduct: 90 pregnant women with inclusion criteria were included in the study from 8 comprehensive health service centers in Jajarm city and its suburbs, and randomly, 45 people were in the control group and 45 people were in the intervention group. The intervention group will then receive 8 sessions of admission-based counseling. The control group will receive only routine care. At the end of the counseling sessions, one month and three months after delivery, the questionnaires are completed by both groups and then the data analysis is performed. Participants/Inclusion and exclusion criteria: Inclusion criteria: First pregnancy, gestational age 28 to 32 weeks, decision to exclusive breastfeeding, obtaining a cut-off score in the questionnaire, no smoking, no pregnancy problems, no major psychiatric illness Inclusion criteria: Not available to pregnant mothers Intervention groups: The intervention group, at separate times, receives 8 sessions of counseling based on acceptance and commitment in such a way that the first 4 sessions twice a week and the second 4 sessions once a week receive 10 people in each session for 90 minutes. The control group only Will receive routine care. Main outcome variables: The first initial consequence is the mental image of the body. The second primary consequence is the self-efficacy of breastfeeding.

Study aim: Investigating the effect of educational intervention based on the TPB in choosing the type of delivery of nulliparous women as well as designing and implementing an appropriate and effective intervention program to reduce cesarean section in pregnant mothers Design: A clinical trial with two control groups, with parallel groups, the sample size in each group 56 people Among the 4 centers conducting childbirth preparation classes in Isfahan, which are economically and culturally identical in pairs, two centers as intervention centers (one center from each economic-cultural level) and two centers as examples. Controls (from each economic-cultural level of a center) will be selected. Thus, among the primiparous pregnant mothers who are eligible for the study, mothers will be included in the intervention and control groups by census until the completion of the sample. Settings and conduct: Field: Education. Location: childbirth preparation classes in Isfahan. The control group: under routine training in PLC classes and the experimental group: under educational intervention based on the theory of planned behavior. Methods: Standard questionnaire as self-report and analysis of results with SPSS software. Participants/Inclusion and exclusion criteria: Inclusion criteria:being a firstborn, no contraindications (medical prohibition) for natural childbirth, not having any physical or mental illness Simultaneously with pregnancy, having a gestational age of 16 to 20 weeks Criteria for not being included in the study: Having a history of childbirth in a pregnant woman Intervention groups: The control group: Routine training in childbirth preparation classes (PLC) The experimental group: Educational intervention based on the theory of planned behavior. Main outcome variables: Perceived attitudes, behavioral intentions, abstract norms, and behavior control, final behavior (natural delivery)

Study aim: Comparison of the effect of postpartum care education through virtual and face-to-face education on women's satisfaction rate Design: A clinical trial with a control group with randomized parallel groups,on 108 participants who used block design metho, in the face-to-face training group; During the initial care (days 1-3), the trainings will be done individually and include all the usual puerperium care, and at the end of the trainings, an educational pamphlet will be provided to the samples Settings and conduct: The content that presented in the intervention and control groups include routine postpartum recommendations; Which is based on the common problems of puerperium per week. In this study, the research environment is Shahrivar 17 and Abuzar Health Center in Ahvaz Participants/Inclusion and exclusion criteria: Inclusion criteria,To give birth to a lively, healthy and term baby in a Normal Vaginal Delivery Single baby,Ability to work with PowerPoint training software and access WhatsApp and messenger,Do not take antidepressants or other specific medications during pregnancy and after childbirth,Have the ability to read and write ,Exclusion criteria,Cases leading to hospitalization, infant death or need for neonatal intensive care,History of depression or other specific illnesses,Having speech and hearing problems Intervention groups: Intervention groups using block design randomization method (6 blocks of 3) are divided into three groups of virtual and face-to-face training and control group, in face-to-face training group; During the initial care (days 1-3), the trainings will be done individually and include all the usual puerperium care, and at the end of the trainings, an educational pamphlet will be provided to the samples. Main outcome variables: satisfaction