: • In accordance with clinical diagnosis or etiologic criteria for coronavirus pneumonia (COVID-19

Study aim: Evaluation of the effect of synbiotic supplementation on inflammatory markers (CRP, ESR, IL-6, CBC) and clinical manifestations before and 8 weeks after treatment in patients with COVID-19 (...) interventional study, patients with COVID-19 are studied; which are randomly divided into case and control groups

Study aim: Overall objective: comparison of three therapies in patients with Super Acute Respiratory Syndrome with and without corona testing for a positive virus Design: Clinical trial with control group, with parallel, two-way blind groups, randomized to 30 patients, random number table was used for randomization. Settings and conduct: After the approval of the plan in the University Research Council and obtaining the code of ethics, sampling will begin among patients who have the conditions to participate in the study. First, randomization will be performed and then individuals will be randomly divided into 3 groups. The study will be blinded in two ways. Vitamin D and C levels are measured in all three groups before the intervention, and patients who are deficient will be included in the study. Then, we will select patients with vitamin D and C deficiency and treat them with vitamin D and vitamin C supplements, and we will study the patient as a control group among other patients who did not have vitamin deficiency. We will examine the rate of recovery in untreated patients with vitamin D and C according to the checklist. Participants/Inclusion and exclusion criteria: Inclusion criteria: the patient was admitted to the acute respiratory center; consent to participate in the study; age 15 years and older. Exclusion criteria: the patient has lung cancer; patients undergoing chemotherapy and radiotherapy. Intervention groups: Group one: taking vitamin D supplements and routine treatment under the supervision of an infectious disease specialist, group two: taking vitamin C supplements and routine treatment under the supervision of an infectious disease specialist and the third group:receiving routine treatment under the supervision of a specialist. Infections are classified as control groups. Main outcome variables: Vitamin D; Vitamin C; RT-PCR results; CT-Scan findings; CX-Ray Findings; CBC; Vital signs; Respiratory Symptoms

months interval from the last vaccine dose, no history of confirmed Covid-19 illness during the first 5 months. Major exclusion criteria: History of allergic reactions after receiving any previous Covid-19

muscle relaxation on sedation of noninvasive mechanically ventilated patients admitted to covid 19 (...) 80 patients with Covid 19 under non-invasive mechanical ventilation admitted to the intensive care (...) years old; Patients admitted to the covid 19 intensive care unit for at least three days; Patients

Study aim: Evaluation of the effect of antibiotic prophylaxis on clinical and patient reported outcome and inflammation-related indicators of oral implant therapy with guided bone regeneration. Design: Clinical trial with control group, double-blind, with parallel groups, randomized, phase 3 on100 patients. A random number table was used for randomization using closed envelopes. Settings and conduct: A total of 100 patients referred to Mashhad Dental School who are applying for implants and at the same time need a bone graft in the form of GBR will be included in this study. For blindness with the help of random number and code for each patient, a person other than the patient surgeon puts the type of intervention in the envelope. data analyzer and the Outcome assessor are blinded in this study. In all groups, one type of graft and membrane is used However, in the intervention group, in addition to routine treatment patients will also have to take 2gr of amoxicillin one hour before work. One week later, pain intensity will be assessed by the visual analog scale and bleeding, swelling and hematoma assessment check-list based on the patient's Yes or No answer. Participants/Inclusion and exclusion criteria: Inclusion criteria:1- An age range 20 to 50 years 2-The extent of the lesion is limited 3-No previous surgical procedures have been initiated in the specific area 4-Absence of systemic disease 5-Non smoker 6-Do not take drug interfere with the treatment process 7- Dehiscence defects in buccal surface of the implant exclusion criteria:1-Do not refer 2-Patients who are allergic to amoxicillin 3-The presence of severe infection 4- Opening the edge of the wound. Intervention groups: Intervention group: In addition to routine treatment, patients receive 2gr amoxicillin an hour before work. control group: Patients will receive routine treatment. Main outcome variables: Pain, Bleeding, Hematoma and swelling

bicarbonate mouthwash on the onset of symptoms attributed to Covid-19 in vaccinated operating room staff of (...) criteria: Get at least two doses of the vaccine, Personnel range of 18-60 years, Do not get Covid-19 in the (...) test will also be taken. Main outcome variables: Covid-19 symptoms, PCR test

obstruction(NLDO) who don't have a history of coagulation disorders; Covid-19 infection and trauma to the

Study aim: Investigating the effect of "nokhod-ab" on the recovery of patients with coronavirus Design: The present study is a clinical trial with a control group, with parallel, randomized group, phase 3 over 40 patients Settings and conduct: The project is being performed at a rehabilitation center for patients with coronavirus. In this study, 40 patients eligible to enter the project are divided into two groups receiving nokodab and routine care. Recipients receive 80 cc of nokodab daily for half an hour before meals for 2 weeks.The control group does not take. Participants/Inclusion and exclusion criteria: Inclusion criteria: 1- Age over 18 year 2-Corona positive test 3-Both men and women 4-Recovery stage Exclusion criteria: 1-Severe kidney disease 2-Liver failure 3- have gout 4-High uric acid 5-Taking medications that induced fatigue Intervention groups: The first group: receiving nokodab The second group: receive routine treatment Main outcome variables: Score of Fatigue Severity based on "Visual Analogue Fatigue Scale"

continuing or making a change in their personal life schedule; (4) contracting COVID-19, and 5) voluntary

psychological symptoms of older adults to prevention of long-covid-19 complications Design: Clinical trial with (...) contracted COVID. Participants/Inclusion and exclusion criteria: Inclusion criteria: 1. History of infection with covid 2. Age over 60 years 3- Consent to participate in the study 4- Having reading and writing

Study aim: Determining the effect of telephone counseling on COVID-19-related health anxiety in pregnant women referred to Saveh health centers Design: This study was a randomized controlled clinical trial. Simple random sampling was performed among pregnant women referring to Saveh Health Center (5

Study aim: Determination of vitamin D supplementation effect on the recovery of hospitalized children suffering from Coronavirus disease 2019 Design: Clinical trial with control group, with parallel groups, double-blind, randomized, on 40 patients. Sealed Envelope online software was used for randomization. Settings and conduct: Children 3 months to 14 years old suffering from Coronavirus disease 2019 admitted to 17 Shahrivar Hospital in Rasht city during 2021 are selected by random sampling method. Patients are randomly divided into two groups by the random block method. An online address (www.sealedenvelope.com) is used to generate a random list. Study groups include intervention group 1: receiving vitamin D at a dose of 1000 IU daily, control group: receiving placebo. To blind the type of intervention, closed and numbered envelopes are used and patients are identified with the same code until the end of the study. The doctor, the evaluator and the patient are blind. Participants/Inclusion and exclusion criteria: Inclusion criteria: Children suffering from Coronavirus disease 2019, 3 to 14 months old hospitalization children in hospital; Exclusion criteria: Children that have a history of hepatitis disease, children that have malabsorption disorder, children that are undergoing chemotherapy Intervention groups: The intervention group is hospitalized children suffering from Coronavirus disease 2019 who will receive daily vitamin D with a dose of 1000 international units. The control group is hospitalized children suffering from Coronavirus disease 2019 who will receive a placebo made by Barij Essan company, daily. Main outcome variables: Time to stop fever, stop respiratory distress and hospitalization

Study aim: In this research, we aim to present the potential role of AAT as an anti-viral and anti-inflammatory agent in SARS-CoV-2 infection. Design: Clinical trial with a control group, with parallel groups, double-blind, randomized, phase 3 on 50 patients. It is used for randomization with blocking based on alpha-1-antitrypsin serum level and random numbers. Settings and conduct: Coronary patients admitted to the ICU of hospitals affiliated to Shahid Beheshti University of Medical Sciences will be evaluated. The present study will be a double-blind randomized controlled clinical trial with parallel groups. The research population is 50 patients. The duration of the study is four weeks and the intervention is weekly. The dose used is 60mg/kgBW and it is an injectable drug. The patient, researcher and health care provider will be blinded. For this purpose, a placebo with the appearance of the drug is used. Participants/Inclusion and exclusion criteria: People who are willing to participate in the research, over 18 years of age, with a positive PCR test for corona or lung involvement in imaging, with oxygen saturation less than 93% in room air, or RR>40 with or without fever. Patients suffering from underlying diseases are not included in the study. People who use anti-coagulant drugs, hormonal drugs, and other illegal drugs, or who consume alcohol, are pregnant or lactating, are not included in the study. Intervention groups: The intervention group received alpha-1-antitrypsin and the control group received placebo (normal saline 0.9%). Main outcome variables: The level of serum alpha-1 antitrypsin, the number of neutrophils and lymphocytes, Mortality rate and hospitalization time, the ratio of neutrophils to lymphocytes, and the serum protein levels of CRP, ESR, interleukin 6, IgA, and anti-IgA antibody.

Study aim: The effect of respiratory and peripheral muscles training on pulmonary and physiological performance in COVID-19 patient Design: Clinical trial with control group, with parallel groups, randomized, on 36 patients. In order to randomize, a simple randomization method using a table of random numbers

in a COVID-19 ward for at least six months, complete mental and physical health based on personal

Study aim: To find out the clinical efficacy of synergistic action of bromhexine hydrochloride and hydroxychloroquine or each drug alone in comparison to placebos on outcome of patients with COVID19 in a controlled and randomized clinical trial Design: Triple blind randomized trial of two drugs in combination and each drug alone compared to placebo in four groups of COVID19 patients receiving, Bromhexine hydrochloride plus Hydroxychloroquine, either drug alone plus placebo of other drug, or two placebos. Settings and conduct: EmamReza Hospital of Tabriz, Iran Participants/Inclusion and exclusion criteria: CIVID19 patients of 18 years and older admitted to hospital fulfilling the enrolment criteria and free of specified exclusion criteria Intervention groups: Four groups of COVID19 patients receiving: group 1) Bromhexine hydrochloride 16 mg q 8 h for 16 days + Hydroxychloroquine, bromhexine 200 mg tablets two tablets q 12 h first day and one tablets q 12 h day 2 to 5, group 2) bromhexine plus placebo of other drug, group 3) hydroxychloroquine + placebo of other drug, group 4) placebos for both of the drugs. Main outcome variables: intensive care transfer, intubation and mechanical ventilation, and survival or death

methods on the level of stress, anxiety, and depression of nurses encountering COVID-19 Design: A (...) . Settings and conduct: The study site will be COVID-19 wards of Khanevadeh and Besat hospitals in Tehran, where nurses working in COVID-19 wards will be selected by available methods. No blinding is performed

requirements: Willingness to participate in the study, Age 20-80 years, Diagnosis of Covid-19 based on PCR

Study aim: Determining the effect of ZAX.1399.C03 on the course of the disease, symptomatic treatment and reduction of inflammatory mediators in COVID-19 patients in home care Design: The triple (...) /Inclusion and exclusion criteria: Admission requirements: 1. Definitive diagnosis of COVID-19 2. Age over 18

ventilation for more than 48 hours; no aspiration symptoms or pneumonia; no infection with Covid-19; no (...) intubation; positive PCR test (infection of Covid-19); re-intubation more than 3 times; apache II score above

Study aim: Determination of dexamethasone treatment in COVID 19 patients in Qom province Design (...) dexamethasone treatment in COVID 19 patients in Qom province, a randomized clinical trial without blindness (...) patients in Beheshti and Forghani hospitals Having COVID 19 That by receiving oxygen by The method of

Study aim: Comparing the impact of educational messages based on an Extended ‎Parallel ‎Process Model on preventive behaviors of the infectious respiratory ‎diseases, with emphasis on COVID-19‏‏‏ (...) perceived threat and effectiveness messages based on EPPM and related to the topic of Covid Preventive

Study aim: Determining the effect of educational intervention based on self-determination theory model on the level of physical activity in students during the pandemic Design: Clinical trial with control group, with parallel groups, blind, randomized, on 112 male and female students Settings and conduct: 112 male and female high school students in Rasht who participated in the study by two-stage random sampling method in two experimental (56) and control (56) groups. Participants/Inclusion and exclusion criteria: Employment to study in the second year of high school Being in the inactive stages of mental readiness to change the behavior of physical activity means one of the stages of pre-thinking, thinking and intention Internet access (via mobile phone or tablet or computer for online or web-based educational interventions) Existence of physical limitations or disability to perform physical activity Having a mental disorder that has been approved by a doctor Reluctance to participate in research Deficiencies in answering questions and unwillingness to complete questionnaires despite warnings Intervention groups: Girls' and boys' high school students of Rasht city were investigated Main outcome variables: Physical activity Conceivable competence Conceivable dependence Conceived autonomy Change preparation steps Efficacy Education status of parents Parents's job Economic status of parents number of familly members

Study aim: Evaluation of the effect of online group support on psychological distress and self-care behaviors of the elderly with type 2 diabetes during the Covid-19 pandemic Design: Parallel randomized superiority controlled trial, using a random blocking allocation that cannot be blinded and sample size will