Study aim: Determining the effectiveness of cognitive-behavioral intervention on sleep quality in patients rescued from acute myocardial infarction Design: Patients were randomly assigned to experimental (cognitive-behavioral internalization according to Beck instructions) and control (routine appointments) by block allocation. The required sample size was 68 people and 34 people were considered in each group. The method of assigning patients to the experimental group and the control group was randomized based on the names of patients discharged from the hospital. Settings and conduct: The research environment of Fatemeh Al-Zahra Hospital in Sari (Mazandaran Heart Center) is in Sari. First, the questionnaires were completed by both groups one week after discharge (before the intervention). Cognitive-behavioral intervention was performed individually in 12 sessions of 45 minutes according to Beck instructions. After a month of rest (because it is a psychotherapy intervention and its effects should be evaluated), the questionnaires were completed again by both groups. Participants/Inclusion and exclusion criteria: Age 30 to 55 years old; discharge with diagnosis of myocardial infarction from the hospital; stable condition of the patient; having the ability to communicate effectively for learning (having a sufficient level of literacy and not having a language barrier and no hearing problems); absence of diagnosed psychological disorder; absence of underlying factors and diseases affecting sleep (COPD) Intervention groups: Intervention group: cognitive-behavioral intervention based on Beck instructions. Control group: has received routine care. Main outcome variables: cognitive behavioral therapy; sleep quality

Study aim: The effectiveness of bioenergy economy training protocols on quality of life, sense of coherence and depression syndromes in patients with asthma Problem Improve daily function of asthma patients' life physically, mentally and energy level by reducing depressive symptoms, increasing quality of life and increasing their sense of coherence. Design: A quasi-experimental type including pre-test and post-test design by forming two groups of subjects and controls. The target statistical population is patients with asthma. Referring to hospital and asthma clinic after interaction and agreement of the clinic and hospital management,d targeted sampling method among them 40 Individuals are selected as statistical samples and are randomly divided into experimental and control groups. Each of the experimental and control groups will be measured twice, first by performing a pre-test and then by performing a post-test, and then the data will be analyzed. Settings and conduct: By referring to the hospital lung clinic and asthma clinic after interaction and agreement of the clinic and hospital management, among all clients with asthma diagnosis and selected by available and targeted sampling method among them 40 Individuals are selected as statistical samples Participants/Inclusion and exclusion criteria: Having any of the 3 degrees of severe, moderate or mild asthma whose severity is known high school degree or higher Ability to do daily exercises & assignments, fill out a questionnaire, use auditory and visual tools Intervention groups: 1- Experimental group: Online implementation of the 40 day bioenergy economy training protocol & sending audio/video files to perform homework. 2- Control group : Sending the protocol brochure at the end of the research. Main outcome variables: Depression, Quality of Life, Sense of Coherence

variables: Students' knowledge about Covid-19

Study aim: Explaining the design, implementation and evaluation of educational program based on multi-theory model on promoting antibiotic prescribing behavior in students of Faculty of Veterinary Medicine, Bahonar University of Kerman Design: A clinical trial with control group, census entry method, was used on 40 veterinary students in the intervention group. Settings and conduct: Bahonar University of Kerman Veterinary School will be the place of intervention and using its educational and laboratory services Participants/Inclusion and exclusion criteria: Inclusion criteria 1- Willingness to participate in research 2- No history of participating in antibiotic resistance training programs 3- Satisfaction to participate in the study 4- Studying as a student in the veterinary doctorate Exclusion criteria 1- Failure to complete the research questionnaire 2- Not participating in training sessions for more than one session Intervention groups: Pre-internship and internship students in veterinary medicine will be Bahonar and Ferdowsi Mashhad University with participating in training and laboratory sessions. the subject of interventions regarding AMR, its side effects, and preventing and reduce its occurrence in their field of work, which will eventually be integrated with One-health approach to reduce the effects of AMR in society. Main outcome variables: Promote and improve the antibiotic administration behavior to prevent the spread of antibiotic resistance in the community

Study aim: To evaluate the effects of cervical manipulation on posture related cervicogenic headache. Design: single blind, parallel assigned, multi-centered, randomized clinical trials will be conducted on 36 participants (two groups with 18 participants each) with history of posture related cervicogenic headache. Settings and conduct: DHQ Gujranwala / Med care international hospital Gujranwala participant kept anonymous for conducting the single blind trial. Participants/Inclusion and exclusion criteria: Male and female participants of age 20 to 40 years with primary complaint of headache. Frequency of at least once a week from minimum of last 3 months and Minimum Neck Disability Index (NDI) disability score of 20 % or greater. joint tenderness exhibited in at least one of the three upper cervical joints (C0-C3) on assessing through manual palpation, non-throbbing and non-lancinating pain of moderate to severe intensity were included into the study. Excluded Having any other primary headaches e.g. migraine or tension headaches, presence of contraindications to cervical spinal manipulation, metabolic diseases, infection, dislocation, osteoporosis, anticoagulant user, chronic corticosteroid user, previous 3 months history of head or neck surgery, previous history of a whiplash injury within six weeks, bilateral headaches, cervical spine stenosis bilateral upper limb symptoms, exhibiting “5 D’s” & “3 N’s” signs and positive and cervical instability tests were excluded from the study. Patient using analgesic drugs. Intervention groups: Group A:The baseline treatment will be 20 minutes of hot pack application and neck isometrics with additional treatment of cervical manipulation. Group B: only received baseline treatment 20 minutes of hot pack + neck isometrics will be performed. Main outcome variables: cervicogenic headache ( pain) Functional disability Quality of life

Study aim: Reduction of viral load and inflammatory cytokines in patients with covid19 Design: Clinical trial with control group, with parallel groups, double-blind, randomized, phase 2.3 on 60 patients. Www.sealedenvelope.com was used for randomization. Settings and conduct: in this study, 60 patients with coronavirus hospitalized in Ali Asghar Hospital in Shiraz who are eligible for inclusion in the study are randomly assigned to one of the three groups of Desferal + Zinc,Zinc and placebo. Dosing: 2 puffs every eight hours for a week In this study, the patients, the physician evaluating the patients, and the person analyzing the statistical inform, are blind. Participants/Inclusion and exclusion criteria: Major inclusion criteria before randomization: Informed and written consent of patient with Coronavirus، Confirmation disease by clinical and laboratory signs، Patients admitted to the ward with moderate symptoms ، 18 to 65 years Major exclusion criteria to study before randomization: Pregnancy and Breastfeeding، concomitant use of vitamin C، Intubated patient، History of Desferal or Zinc allergy Intervention groups: 1-Nasal spray Desferal + Zinc,chemical ingredients: desferrioxamine (500mg) plus Zinc acetate (200 mg) in a volume of 10 cc. 2-Nasal spray Zinc,chemical ingredients: Zinc acetate (200 mg) in a volume of 10 cc 3-control group:Nasal spray containing 10 cc of distilled water. Dosing: 2 Puffs in the nose every eight hours for a week Main outcome variables: Interleukin 6, Body temperature, Cough, Oxygen saturation

Study aim: evaluation of the effect size of extraocular myofascial release technique on the angle of deviation in non-accommodative Eso deviations Design: A self-controlled clinical trial, single-arm, phase 2-3 Settings and conduct: Patients with non-accommodative Eso deviation due to convergence spasm remain without treatment intervention for a week after measuring the deviation near and far. At the end of the no-treatment week, the angle of deviation and the saccades' velocity will be measured. Then, the treatment intervention (extraocular myofascial release technique) is performed in two stages during one week for both eyes. At the end of this week, the angle of deviation and the saccades' velocity will be measured again, and their results will be compared. Study location: Optometry Clinic, School of Rehabilitation, Iran University of Medical Sciences Participants/Inclusion and exclusion criteria: Participants: Young people with convergence spasm Inclusion criteria: Age: 20 to 35 years Cyclofraction less than +1.00 D Visual acuity of 20/20 or better with correction Esophoria or Esotropia at near or far after complete refractive correction Normal AC/A ratio (2.86±2.40) (Mean ± SD) Comitancy of the deviation angle The occurrence of deviation or related symptoms in less than one year Exclusion criteria: Use of any drug affecting the central nervous system Any underlying disease and drug usage History of the head or eye trauma History of strabismus surgery Intervention groups: Patients with non-accommodative Eso deviation due to convergence spasm remain without therapeutic intervention for a week (control). Then the therapeutic intervention (releasing myofascial tissue for the medial rectus and related connective tissue for at least 300 seconds for each eye) is performed in two stages during the following week (intervention). Main outcome variables: The magnitude of Eso deviation

Study aim: Evaluation of clinical and radiographic conditions of implants placed with closed sinus lift technique with and without bone graft Design: Clinical trial with control group, double-blind, randomized, on 40 patients. A random number table was used for randomization using closed envelopes Settings and conduct: A total of 40 patients in need of implants in the posterior maxilla region with a minimum bone height of 5 mm referred to prosthodontics and implant dentistry, Mashhad Dental School, are selected for the study. Patients are randomly sorted into two groups of closed sinus lifts with and without bone graft materials by a random number table. The closed sinus lift surgical procedure for both groups is as follows: before the implant is placed, the Sinus lift is closed. Then, in one group, the bone graft material is used simultaneously as elevating the sinus lift. In the other group, this procedure is performed without the graft material, and then the implant is placed. Dental CBCT images are taken before surgery and six months after surgery. In addition, PA radiographic images are also taken before surgery, instantly after surgery, 3and 6 months later. Bone height is measured and evaluated at different distances with those images. Participants/Inclusion and exclusion criteria: Inclusion criteria: 1. Patients over 18 years of age 2.The missing tooth in the posterior maxillary area 3. At least 5 mm bone height exclusion criteria: 1.Having a Medical contraindication for implant surgery 2.Rupture of the sinus membrane during surgery 3.Implant loss Intervention groups: In the intervention group, the bone graft is placed concurrently with elevating the sinus in a closed method to increase the thickness and height of the bone, and then an implant is placed. Main outcome variables: vertical bone gain, pain, swelling

of COVID-19 disease epidemic, this study will be through the provision of virtual content (audio

Study aim: Determining the effect of moderate oral triglyceride administration on the course of symptoms in outpatients with viral respiratory tract infection with metabolic syndrome Design: Clinical trial with control group, with parallel groups, without blinding, randomized, phase 3 on 80 patients. Random Allocation Software was used for randomization. Settings and conduct: First, patients referred to viral respiratory tract infection and metabolic syndrome are identified to Afzalipour Medical Center within a 6 months. Then they enter the study based on entry and exit criteria and based on random sampling and after obtaining informed consent. At this stage, their demographic information will be recorded and the drug will be studied and the relevant training will be provided to them. Body temperature, number of breaths per minute, rate of body pain, cough and side effects using a questionnaire that the patient must fill in on days zero (referral time) 1, 2, 3, 4, 7, 14 to both groups of intervention and Controls are evaluated. Participants/Inclusion and exclusion criteria: Admission Requirements: Metabolic Syndrome as defined by the International Diabetes Federation (IDF) Non-entry conditions: Allergy to the drug Pregnancy / breastfeeding Asthma and allergies Congestive heart failure Chronic renal failure Malignancy Immune system defects Intervention groups: Intervention group: Administration of oral medium-chain triglyceride at a dose of 2 tablespoons after each meal and daily recording of symptoms Control group: daily recording of symptoms Main outcome variables: Cough intensity; Number of coughs; Breathing speed; body pain; Fever; death; Hospitalization

Study aim: Assessment of the safety and efficacy of Basalin® insulin glargine in type 2 diabetic patients Design: A post-marketing-survey of phase 4 on 400 type 2 diabetic patients. Settings and conduct: This prospective postmarketing study will be performed on 400 type 2 diabetic patients referred to endocrine and metabolism research centers. After qualifying for inclusion in the study, the study protocol will be explained to the patient. After obtaining informed consent, each patient will be followed up for 6 months from the start of insulin or until the day of discontinuation of the drug if necessary. Patient information such as demographics, medications, and vital signs are entered in the CRF form. Then, Basalin insulin glargine, which is in the form of 100 U / ml pens and is injected subcutaneously, will prescribed to patients by an endocrinologist. How to start and adjust the dose of Basalin will be based on the ADA 2020 protocol. Each patient is given a glucometer to measure blood sugar and is taught how to measure blood glucose. A booklet is also delivered to the patient to record the amount of blood glucose and brings in each visit At each visit, the patient is examined for any drug-related side effects. If necessary, the dose of medication will be adjusted by the treating physician. Participants/Inclusion and exclusion criteria: Type 2 diabetic patients of both sexes who have been treated with oral hypoglycemic drugs for at least 6 months prior to the study and have not achieved their diabetes control goals. Also, patients have not received long-acting insulins in the last 6 months. Intervention groups: After being eligible for the study participation and obtaining informed consent, all patients will be treated with subcutaneously insulin glargine Basalin for 6 months. Main outcome variables: -Changes in glycated hemoglobin -Changes in blood glucose

Study aim: Effect of Atorvastatin to decrease intensity of clinical manifestations in patient with COVID19 Design: Clinichal trial with control group and parallel groups, double blind, with using a permuted balanced block randomization method with the size of blocks 4 and 6, phase 3 on 100 patients, Random sequence will be generated by running an online program in sealed envelope website (https://www.sealedenvelope.com/). Settings and conduct: The aim of this study is evalution of Atorvastatin effect in reducing clinical manifestation of COVID19.Locality of the study is in Amiralmomenin and Khansari hospital of Arak city.In Atorvastatin group, Atorvastatin 40 mg tablet orally (or with gavage in intubated patients) will be added to routine treatment protocol for 10 days from first day and in control group flour tablet that is similar to Atorvastatin will be given to the patients (in addition to routine treatment) for 10 days from first day, too. Participants/Inclusion and exclusion criteria: Inclusion criteria: Patients with 18 to 75 years old Positive PCR for COVID19 in patients who refer to Amiralmomenin and Khansari hospital of Arak city Having the informed consent Non-inclusion criteria: long time use of Statins Pregnancy and loctation History of sensitivity to Statins Chronic renal failure long time treating with Colchicine, Cyclosporine, Digoxin, Azole antifungal agents, Niacin Intervention groups: In Atorvastatin group, Atorvastatin 40 mg tablet for 10 days from first day will be added to routine treatment protocol and in control group flour tablet that is similar to Atorvastatin will be given to the patients (in addition to routine treatment). Main outcome variables: Duration of having fever, Duration of having cough, Atrial oxygen saturation, Duration of intubation, Duration of invasive or non invasive oxygen therapy, Length of hospitalization, Length of ICU stay, Releasing or death

Study aim: Comparative investigation between the effectiveness of aromatherapy with Lavandula angustifolia and counselling based on Mindfulness-based Cognitive Therapy for sexuality (MBCT-S) on the sexual function of married women in reproductive age Design: A clinical trial consisting of two intervention groups and a control group, with parallel groups, on 60 married women. Random allocation software is used for randomization. Settings and conduct: Aromatherapy group: daily use of lavender essential oil Sexual counseling group with mindfulness-based cognitive therapy approach: 8 sessions of group counselling Participants/Inclusion and exclusion criteria: Inclusion criteria :Women 18-49 years ,Married ,Being sexually active Exclusion criteria :Happening of major stress during 3 month ago, Smelling disorder, Pregnancy, Sensitivity to lavender essential oil, Digestive disorders, Absence of the spouse Intervention groups: 1. Aromatherapy group: 2-3 drops of lavender essential oil are poured daily on a napkin daily and inhaled from a distance of 20 cm. 2. Sexual counseling group with mindfulness-based cognitive therapy approach: In 8 sessions of 120 minutes (one session per week), they will receive group sexual counseling with mindfulness-based cognitive therapy approach. 3. Control group: no intervention. Main outcome variables: The rate of sexual function

intervention groups by rolling the dice). Settings and conduct: Due to the prevalence of Covid-19 disease

Study aim: Determine the effectiveness of psychological interventions on Mental health of health personnel working in hospitals and clinics of KMU During the period of the corona virus outbreak Design: an empirical intervention based educational research, With pre-test and post-test of control and intervention groups, Simple randomization with sample size of 60 people Settings and conduct: The present study is an empirically based educational intervention with a pretest-posttest and intervention and control group design which will be done after approval of the code of ethics by Kerman University of Medical Sciences. Then, the questionnaire link will be posted on the college website to gain statistical population. The public relations department of the University will call for the health care staff under the supervision of Kerman University of Medical Sciences to answer this questionnaire and those who are hospitalized or depressed based on their scores and would like to participate in the study. They were randomly divided into intervention and control groups and entered the study. The intervention group will be comprised of a psychological counseling program consisting of 10 daily sessions through virtual networks such as WhatsApp or Skype for 30 to 45 minutes individually. The post-test will be given to the two groups after the training sessions. Participants/Inclusion and exclusion criteria: Inclusion criteria :Satisfaction to participate in the study, Health or medical staff at Corona Screening Reference Clinics, No Coronavirus Disease now. Exclusion criteria :Do not attend two or more counseling sessions. Intervention groups: Intervention group: Psychological counseling program consisting of 10 daily virtual sessions through virtual networks such as WhatsApp or Skype For 30 to 45 minutes. Control group: There is no intervention. Main outcome variables: Anxiety, depression

Study aim: The efficacy of Thalidomide in severe Covid19 pneumonia Design: This study is a two arm parallel group clinical trial that will be done in Khorshid hospital. Randomization is done through block method. Sample size of this study is 60 patients that divided equally into two groups. Both groups treat with the same method, except the case group that receive thalidomide tablet. This a phase 3 clinical trial. In both groups clinical outcome and side effects are evaluated. Settings and conduct: A randomized clinical trial that will be done in Khorshid hospital. According to inclusion and exclusion criteria, patients are randomly divided into 2 grups. Both groups receive the same treatment. Trial group will be received thalidomide tablet daily until 14 days. Participants/Inclusion and exclusion criteria: Inclusion criteria: 1- 18-75 year old men and 50-75 year old women admitted in hospital 2-Spo2 less than 85% in admission 3-Clinical symptoms and signs compatible with COVID19 infection and positive PCR test or lung HRCT abnormalities compatible with COVID19 pneumonia 4-No need to intubation in first 24 hour of admission 5-No multiorgan failure at presentation 6- No shock state at presentation 7- Obtained informed consent Exclusion criteria: 1. Hepatic failure (Child Pugh score ≥ C, AST> 5 times of the upper limit normal) 2. Severe renal dysfunction (GFR less than 30cc per min) Intervention groups: Both case and control group receive hydroxychloroquine tablet 100 mg BD for 5 days, acetaminophen codeine and syrup Diphenhydramine for symptom control, Antibiotics depend on physician choice (Ceftriaxone, Azithromycin, Vancomycin), Amp Enoxaparin 40 mg SC daily during hospitalization and Amp Methylprednisolone 50 mg IV daily for 7 days. trial group receive thalidomide tablet 100 mg for 14 days. Main outcome variables: Time to clinical recovery, Intubation rate, Time to intubation

Study aim: Evaluation of the effect of Tranilast on the effectiveness of antiviral drug treatment in patients with severe COVID19 Design: This study is a two arm parallel group clinical trial that will be done in Ahvaz hospital. Randomization is done through block method. Sample size of this study is 60 patients that divided equally into two groups)intervention and control group . intervention and control group treat with the same method, except the case group that receive300 mg daily for 7 days (100 mg PO TDS). This a phase 3 clinical trial. In both groups clinical outcome and side effects are evaluated. Settings and conduct: A randomized clinical trial that will be done in َAhvaz hospital. According to inclusion and exclusion criteria, patients are randomly divided into 2 grups. Both groups receive the same treatment. Intervention group will receive 300 mg daily for 7 days (100 mg PO TDS).Participants in this study, as well as outcome assessors, were kept blind Participants/Inclusion and exclusion criteria: .Age ≥18 years Laboratory polymerase chain reaction (PCR) confirmed infection with COVID19 Lung involvement confirmed with chest imaging Hospitalized with:Cough Less than 8 days since illness onset Willingness of study participant to accept randomization to any assigned treatment arm Acceptance of non-participation in another study before the 28th day of the study؛ Intervention groups: Both intervention and control group receive routine treatment for two weeks. Intervention group receive 3 Tranilast tablet 100 mg for 7 days. Main outcome variables: Time to clinical recovery,respiratory signs، Intubation rate,Number of ICU-admitted patients، Duration of ICU-admission، neutrophil-lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR) ، C-reactive protein (CRP).

Study aim: Effect of High Doses of Vitamin C on Coagulation Factors and Vascular endothelium in Sepsis Patients Design: A controlled, parallel-group, single-blind, randomized, phase 3 clinical trial on 50 patients. Block Randomization was used for randomization. Settings and conduct: This RCT study will be conducted in the special care units of Sinai Hospital in 2018-2019. Adult patients with sepsis who are hospitalized in the intensive care unit and meet the inclusion criteria, after obtaining the form Consent will be included in the study. Patients will be randomly divided into two groups of 25 people - 1:1 through Block Randomization. • The first group, in addition to the standard treatment, 25 mg/kg of vitamin C as a bolus every six hours for 72 hours. will receive and • The second group will receive only the standard treatment. a sample is taken from them and checked in the laboratory Participants/Inclusion and exclusion criteria: Entry requirements: Having sepsis according to the criteria stated in the Surviving Sepsis Campaign 2016 Guideline based on SOFAScore Non-entry conditions: Age less than 18 years • Age above 80 years • pregnancy • kidney failure: AKI according to the definition of KDIGO guidelines • Receiving other antioxidants 24 hours before and during the study (NAC, melatonin and selenium) • Receiving intravenous fibrinogen • Receive intravenous PCC • Receiving heparin with a therapeutic dose INR˃1.5 • (PLT˂100000) Thrombocytopenia • Patients receiving warfarin • Hemochromatosis patients Chronic renal failure (GFR<40) • More than 48 hours have passed since the onset of sepsis Intervention groups: In addition to the standard treatment, the first group will receive 25 mg/kg of vitamin C as a bolus every six hours for 72 hours. The second group will receive only the standard treatment. Main outcome variables: Syndecan-1,CRP/ALB ratio, ACR, FDP/D-Dimer Ratio, Antithrombin 3, fibrinogen

Study aim: The effect of the online child birth preparation classes on anxiety and the quality of life of pregnant women during covid-19 pandemy Design: This research is a randomised clinical trial with two control and intervention group.50 pregnant women are selected randomly in each group.No

Study aim: Evaluating effectiveness of saffron and herbal formula (based on chamomile) on respiratory symptoms and inflammatory biomarkers of pulmonary chemical veterans in comparison to placebo Design: Randomized, controlled, phase 3, parallel groups, clinical trial on 160 pulmonary chemical veterans. َAfter stratification based on underlying disease, participants will be divided into 4 groups using block randomization method with random allocation software (SPSS). In Strata 1, Groups 1 and 2 receive herbal syrup or its placebo 10 cc every 12 hours and in strata 2, groups 1 and 2 receive saffron capsule or its placebo 1 capsule every 12 hours. Settings and conduct: This trial will be held in Tehran Baqiyatallah hospital. After informing the public, volunteers who have inclusion criteria will be divided randomly into 4 groups. They are not aware that they are in intervention group or placebo group. Respiratory symptoms will be evaluated at weeks 0, 4, and 8 and inflammatory markers will be assessed at weeks 0 and 8 and data will be analyzed using SPSS software. Participants/Inclusion and exclusion criteria: Mustard gas pulmonary chemical veterans aged 40-65 years old Intervention groups: Strata 1: Group 1: herbal syrup Group 2: herbal placebo Strata 2: Group 1: saffron capsule Group 2: placebo capsule Main outcome variables: Dyspnea severity; Cough severity

Study aim: Safety evaluation of umbilical cord derived mesenchymal stem cells in multiple sclerosis patients Design: This study is a phase 1 clinical trial, the main purpose of which is to investigate the safety and efficacy of placental mesenchymal stem cells in 5 patients with secondary progressive MS without blinding. Settings and conduct: The injection of mesenchymal stem cells intravenously at the rate of one million per kilogram of body weight is performed without stopping the monoclonal antibody drugs at Baqiyatullah Hospital in Tehran. Participants/Inclusion and exclusion criteria: 1) Age between 18 and 55 2) Diagnosed of MS based on the criteria given by McDonalds 3) EDSS score between 2 and 7 after at least 3 months have passed since the last attack 4) secondary progressive patients who are treated with monoclonal antibodies Intervention groups: At the rate of one million per kilogram of body weight (6*10) stem cells are injected into patients, and this amount is administered intravenously (IV). Main outcome variables: Side effects of MSCs on neurophysiological functions, clinical symptoms and immunological processes

Study aim: Comparison of effectiveness of rifaximin at doses of 1650mg and 2200mg in the treatment of patients with diarrhea-predominant irritable bowel syndrome. Design: This is an open-label, parallel, phase III and randomized clinical trial with control group. Randomization is done using SPSS software. The estimated sample size is 150 patients. Settings and conduct: Place of study: clinic of digestive diseases at Rasoul-e-Akram Hospital, Tehran, Iran; The target population: adult patients with diarrhea-predominant irritable bowel syndrome; Blinding: there is no blinding in this study. Participants/Inclusion and exclusion criteria: Inclusion criteria:Diarrhea-dominant IBS patients ; who are available for the entire study period; 16-70 years old. Exclusion criteria: other sub-classes of IBS; Antibiotic and probiotics therapy in the last 3 months; inflammatory bowel disease. Intervention groups: Control group: 550mg capsule of Rifaximin three times a day. Intervention group: 550mg capsule of Rifaximin four times a day. Main outcome variables: abdominal pain, stool consistency, frequency/urgency in defecation, and the quality of life

Study aim: Determining the effect of manual ventilation with mechanical ventilation on arterial blood gases, end-expiratory carbon dioxide and arterial blood oxygen saturation of patients under mechanical ventilation during cardiopulmonary resuscitation. Design: A clinical trial with a control group, with parallel groups, Single blind , randomized, For randomization, permutation block random allocation with size 6 and the site www.sealedenvelop.com will be used; The said site randomly generates 11 blocks of size 6. Settings and conduct: Methodology: After allocating patients to the control and intervention groups and obtaining informed consent, cardiopulmonary resuscitation will be performed in both groups based on the latest guidelines, and ventilation will be performed using one of the two common methods (mechanical ventilation or manual ventilation). Place of study: Hospital and Imam Reza Hospital in Mashhad Participants/Inclusion and exclusion criteria: Inclusion criteria: Definitive cardiopulmonary arrest diagnosis , Patients with neuropathy diseases with cv-line Exclusion criteria: Traumatic cardiac arrest, Irreversible death, Pregnant Intervention groups: The intervention group will receive ventilation during cardiopulmonary resuscitation through RESMED mechanical ventilation device with volume controlled ventilation (VCV) mode settings.The control group will receive manual ventilation during cardiopulmonary resuscitation through an ambobag. Main outcome variables: End-tidal carbon dioxide; arterial oxygen saturation; arterial blood gases

Study aim: Investigating the rate of wound dehiscence and infection of surgical wound using two Methods of skin stapler and nylon thread in closing the wound of diabetic patients undergoing total knee replacement surgery Design: Clinical trial, with control group, with parallel groups, without blinding, randomized on 120 patients. The participants will be randomly listed using computer software (RAS) into two groups of closure with nylon suture and closure with staples using permutation blocks in 15 blocks of 8. Settings and conduct: The study will take place in the medical center of Lar city. All diabetic patients undergoing total knee arthroplasty will be operated with the same techniques and tools. All patients will be operated from sub vestus approach and with PFC sigma depuy prosthesis by one surgeon. Participants/Inclusion and exclusion criteria: Inclusion criteria: definitive diagnosis of diabetes through examination of tests; fasting blood sugar between 70 and 130; Exclusion criteria: History of cancer and chemotherapy, uncontrolled internal and vascular diseases; Reduction of blood albumin; Taking systemic corticosteroid drugs before surgery; Having a history of knee surgery or the presence of scars and wounds in the knee area Intervention groups: Intervention group: Using skin stapler to close the surgical wound; Control group: using nylon suture to close the surgical wound Main outcome variables: Wound infection, wound dehiscence

Study aim: Investigating the therapeutic effect of kalimba music on cognitive, speech and motor rehabilitation of patients with ischemic stroke Design: Clinical trial, with control group, with parallel groups, without blinding, phase 0 on 620 patients. The rand function of Excel software was used for randomization. Settings and conduct: We are considering that the music therapy process of the patients will take place within 4-5 months (16 half-hour sessions) in the office of a neurologist. The control group will continue with the predetermined treatments in the medical system, including drug therapy, physical therapy, speech therapy, occupational therapy, and rehabilitation. The experimental group will also use music therapy as a complementary (and not a substitute) treatment in addition to the aforementioned treatment methods. Participants/Inclusion and exclusion criteria: Society: People with ischemic stroke in the anterior and middle cerebral artery less than 1 year have passed since their stroke and have complications such as speech disorder, half body paralysis, depression and cognitive complications; The age of these people is in the range of 55 to 75 years and they have the same risk factors and drugs. Intervention groups: An educational program including playing the kalimba instrument with very simple rhythms in the initial sessions to playing more complex rhythms for the final sessions will be developed and will be taught to the patients. The patient will play these rhythms (including the repetition of 4-20 notes) in the presence of the therapist's music during therapy sessions. The control group will receive only the usual methods included in the treatment protocol, including drug therapy, physical therapy, rehabilitation, and speech therapy. Main outcome variables: music therapy؛ stroke؛ playing؛ Kalimba؛ cognitive؛ speech؛ anterior cerebral artery؛ ischemic stroke